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调节性T细胞（TREG）（TCD4 + CD25 + FOXP3 +）在麻风病不同临床类型及反应状态中的分布。

T regulatory cells (TREG)(TCD4+CD25+FOXP3+) distribution in the different clinical forms of leprosy and reactional states.

作者信息

Parente José Napoleão Tavares, Talhari Carolina, Schettini Antônio Pedro Mendes, Massone Cesare

机构信息

Centro Universitário Christus, Fortaleza, CE, Brazil.

Universidade Estadual do Amazonas, Manaus, AM, Brazil.

出版信息

An Bras Dermatol. 2015 Jan-Feb;90(1):41-7. doi: 10.1590/abd1806-4841.20153311.

DOI:10.1590/abd1806-4841.20153311
PMID:25672298
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4323697/
Abstract

BACKGROUND

Leprosy is characterized histologically by a spectrum of different granulomatous skin lesions, reflecting patients' immune responses to Mycobacterium leprae. Although CD4+CD25+ FoxP3+ T regulatory cells are pivotal in the immuneregulation, presence, frequency, and distribution of Tregs in leprosy, its reactional states have been investigated in few studies.

OBJECTIVES

This study aimed to verify the frequency and distribution of regulatory T cells in different clinical forms and reactional states of leprosy.

METHODS

We performed an immunohistochemical study on 96 leprosy cases [Indeterminate (I): 9 patients; tuberculoid tuberculoid: 13 patients; borderline tuberculoid: 26 patients; borderline borderline: 3 patients; borderline lepromatous: 8 patients; lepromatous lepromatous: 27 patients; reversal reaction: 8 patients; and erythema nodosum leprosum: 2 patients].

RESULTS

FoxP3-positive cells were present in 100% of the cases with an average density of 2.82% of the infiltrate. Their distribution was not related to granulomatous structures or special locations. There was a statistically significant increment of FoxP3 expression in patients with leprosy reversal reactions when compared with patients presenting with type I leprosy (P= 0.0228); borderline tuberculoid leprosy (P = 0.0351) and lepromatous leprosy (P = 0.0344).

CONCLUSIONS

These findings suggest that Tregs play a relevant role in the etiopathogenesis of leprosy, mainly in type I leprosy reaction.

摘要

背景

麻风病在组织学上的特征是一系列不同的肉芽肿性皮肤病变，反映了患者对麻风分枝杆菌的免疫反应。虽然CD4 + CD25 + FoxP3 + T调节细胞在免疫调节中起关键作用，但关于麻风病及其反应状态中Tregs的存在、频率和分布的研究较少。

目的

本研究旨在验证不同临床类型和反应状态的麻风病中调节性T细胞的频率和分布。

方法

我们对96例麻风病患者进行了免疫组织化学研究[未定类（I）：9例；结核样型：13例；界线结核样型：26例；中间界线类：3例；界线类偏瘤型：8例；瘤型：27例；升级反应：8例；麻风结节性红斑：2例]。

结果

100%的病例中存在FoxP3阳性细胞，平均密度为浸润细胞的2.82%。它们的分布与肉芽肿结构或特殊位置无关。与I型麻风病患者（P = 0.0228）、界线结核样型麻风病患者（P = 0.0351）和瘤型麻风病患者（P = 0.0344）相比，麻风病升级反应患者的FoxP3表达有统计学显著增加。

结论

这些发现表明Tregs在麻风病的发病机制中起相关作用，主要在I型麻风反应中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/13eeb6534353/abd-90-01-0041-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/0174cc2e1137/abd-90-01-0041-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/8ff3f09ca96b/abd-90-01-0041-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/2e051a86947f/abd-90-01-0041-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/d9db2144912e/abd-90-01-0041-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/3b24f34d396a/abd-90-01-0041-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/ec8869bd58c7/abd-90-01-0041-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/1e821eeecb51/abd-90-01-0041-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/13eeb6534353/abd-90-01-0041-g08.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/0174cc2e1137/abd-90-01-0041-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/8ff3f09ca96b/abd-90-01-0041-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/2e051a86947f/abd-90-01-0041-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/d9db2144912e/abd-90-01-0041-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/3b24f34d396a/abd-90-01-0041-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/ec8869bd58c7/abd-90-01-0041-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/1e821eeecb51/abd-90-01-0041-g07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7bea/4323697/13eeb6534353/abd-90-01-0041-g08.jpg

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