麻风病发病机制与遗传学的新见解
New insights in the pathogenesis and genetics of leprosy.
作者信息
Gulia Andrea, Fried Isabella, Massone Cesare
出版信息
F1000 Med Rep. 2010 Apr 27;2:30. doi: 10.3410/M2-30.
Abstract
In the last 30 years the leprosy burden has been dramatically reduced but over the last 5 years still more than 200,000 new cases were detected each year. Advances in immunology, pathogenesis, and genetics of leprosy have been reported. A deeper understanding of the mechanisms of infection will ultimately improve our ability to fight against this potentially devastating infectious disease.
摘要
在过去30年里，麻风病负担已大幅减轻，但在过去5年中，每年仍有超过20万新病例被发现。麻风病在免疫学、发病机制和遗传学方面都有进展的报道。对感染机制的更深入了解最终将提高我们对抗这种可能具有毁灭性的传染病的能力。
相似文献
1
New insights in the pathogenesis and genetics of leprosy.麻风病发病机制与遗传学的新见解
F1000 Med Rep. 2010 Apr 27;2:30. doi: 10.3410/M2-30.
2
Advances in the Immunology and Genetics of Leprosy.麻风病免疫学与遗传学进展
Front Immunol. 2020 Apr 16;11:567. doi: 10.3389/fimmu.2020.00567. eCollection 2020.
3
[Leprosy in Africa. Current status and epidemiological significance].[非洲的麻风病。现状及流行病学意义]
Fortschr Med. 1992 Apr 10;110(10):170-3.
4
Learning from leprosy: insights into contemporary immunology from an ancient disease.从麻风病中学习：从一种古老疾病洞察当代免疫学。
Skin Pharmacol Appl Skin Physiol. 2002 Jan-Feb;15(1):1-6. doi: 10.1159/000058177.
5
Leprosy as a genetic model for susceptibility to common infectious diseases.麻风病作为常见传染病易感性的遗传模型。
Hum Genet. 2008 Apr;123(3):227-35. doi: 10.1007/s00439-008-0474-z. Epub 2008 Feb 5.
6
Leprosy in the post-elimination phase: so near and yet so far.消除后阶段的麻风病：近在咫尺，却又遥不可及。
G Ital Dermatol Venereol. 2020 Jun;155(3):269-279. doi: 10.23736/S0392-0488.19.06249-7. Epub 2019 Apr 23.
7
Genetics of susceptibility to leprosy.麻风易感性的遗传学
Genes Immun. 2002 Dec;3(8):441-53. doi: 10.1038/sj.gene.6363926.
8
Leprosy.麻风病
Curr Opin Neurol. 2000 Jun;13(3):317-22. doi: 10.1097/00019052-200006000-00015.
9
Leprosy in French Polynesia.法属波利尼西亚的麻风病。
New Microbes New Infect. 2019 Feb 7;29:100514. doi: 10.1016/j.nmni.2018.10.010. eCollection 2019 May.
10
[Leprosy, a pillar of human genetics of infectious diseases].[麻风病，人类传染病遗传学的一个支柱]
Pathol Biol (Paris). 2013 Jun;61(3):120-8. doi: 10.1016/j.patbio.2013.03.003. Epub 2013 May 24.
引用本文的文献
1
Correlation of Histomorphological Findings with Bacteriological Index in Leprosy Patients.麻风病患者组织形态学结果与细菌学指标的相关性
Iran J Pathol. 2022 Winter;17(1):48-55. doi: 10.30699/IJP.2021.534122.2682. Epub 2021 Dec 15.
2
Current approaches and future directions in the treatment of leprosy.麻风病治疗的当前方法与未来方向。
Res Rep Trop Med. 2012 Aug 1;3:79-91. doi: 10.2147/RRTM.S27395. eCollection 2012.
3
Impact of -308 G>A (rs1800629) gene polymorphism in modulation of leprosy risk: a reappraise meta-analysis of 14 case-control studies.-308 G>A（rs1800629）基因多态性对麻风病风险调节的影响：14 项病例对照研究的再评价荟萃分析。
Biosci Rep. 2017 Oct 27;37(5). doi: 10.1042/BSR20170806. Print 2017 Oct 31.
4
T regulatory cells (TREG)(TCD4+CD25+FOXP3+) distribution in the different clinical forms of leprosy and reactional states.调节性T细胞（TREG）（TCD4 + CD25 + FOXP3 +）在麻风病不同临床类型及反应状态中的分布。
An Bras Dermatol. 2015 Jan-Feb;90(1):41-7. doi: 10.1590/abd1806-4841.20153311.
5
Lack of Association of the Polymorphisms IL-17A (-197G/A) and IL-17F (+7488A/G) with Multibacillary Leprosy in Mexican Patients.白细胞介素 17A(-197G/A)和白细胞介素 17F(+7488A/G)多态性与墨西哥患者的多菌型麻风病无关。
Int J Genomics. 2014;2014:920491. doi: 10.1155/2014/920491. Epub 2014 Nov 6.
6
Lupus and leprosy: beyond the coincidence.狼疮与麻风病：绝非巧合。
Immunol Res. 2015 Feb;61(1-2):160-3. doi: 10.1007/s12026-014-8596-y.
7
Association of genetic polymorphism of HLA-DRB1 antigens with the susceptibility to lepromatous leprosy.HLA-DRB1抗原基因多态性与瘤型麻风易感性的关联
Biomed Rep. 2013 Nov;1(6):945-949. doi: 10.3892/br.2013.167. Epub 2013 Sep 19.
8
Inhibition of angiogenesis as a new therapeutic target in the treatment of lepromatous leprosy.抑制血管生成作为治疗瘤型麻风的新治疗靶点。
Clin Cosmet Investig Dermatol. 2012;5:1-6. doi: 10.2147/CCID.S26200. Epub 2011 Dec 29.
本文引用的文献
1
Presence of intestinal helminths decreases T helper type 1 responses in tuberculoid leprosy patients and may increase the risk for multi-bacillary leprosy.肠道寄生虫的存在会降低结核样型麻风患者的辅助性 T 细胞 1 型应答，并可能增加多菌型麻风的发病风险。
Clin Exp Immunol. 2010 Jul 1;161(1):142-50. doi: 10.1111/j.1365-2249.2010.04164.x. Epub 2010 Apr 9.
2
T regulatory cells and plasmocytoid dentritic cells in hansen disease: a new insight into pathogenesis?麻风病中的调节性T细胞和浆细胞样树突状细胞：对发病机制的新见解？
Am J Dermatopathol. 2010 May;32(3):251-256. doi: 10.1097/DAD.0b013e3181b7fc56.
3
alpha1-acid glycoprotein as a putative biomarker for monitoring the development of the type II reactional stage of leprosy.α1-酸性糖蛋白作为监测麻风病 II 型反应期发展的潜在生物标志物。
J Med Microbiol. 2010 Apr;59(Pt 4):400-407. doi: 10.1099/jmm.0.016394-0. Epub 2010 Jan 14.
4
Integrated pathways for neutrophil recruitment and inflammation in leprosy.麻风病中性粒细胞募集和炎症的综合途径。
J Infect Dis. 2010 Feb 15;201(4):558-69. doi: 10.1086/650318.
5
Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility.常见麻风病易感性 MRC1 外显子 7 多态性的遗传和功能分析。
Hum Genet. 2010 Mar;127(3):337-48. doi: 10.1007/s00439-009-0775-x. Epub 2009 Dec 25.
6
A common genetic fingerprint in leprosy and Crohn's disease?麻风病和克罗恩病存在共同的基因指纹？
N Engl J Med. 2009 Dec 31;361(27):2666-8. doi: 10.1056/NEJMe0910690. Epub 2009 Dec 16.
7
Genomewide association study of leprosy.麻风病的全基因组关联研究。
N Engl J Med. 2009 Dec 31;361(27):2609-18. doi: 10.1056/NEJMoa0903753. Epub 2009 Dec 16.
8
Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis.麻风病中的脂滴形成：参与花生四烯酸形成和麻风分枝杆菌发病机制的 Toll 样受体调节细胞器。
J Leukoc Biol. 2010 Mar;87(3):371-84. doi: 10.1189/jlb.0609433. Epub 2009 Dec 1.
9
Comparative genomic and phylogeographic analysis of Mycobacterium leprae.麻风分枝杆菌的比较基因组学和系统地理学分析。
Nat Genet. 2009 Dec;41(12):1282-9. doi: 10.1038/ng.477. Epub 2009 Nov 1.
10
Mycobacterium leprae induces insulin-like growth factor and promotes survival of Schwann cells upon serum withdrawal.麻风分枝杆菌诱导胰岛素样生长因子，并在血清撤离时促进许旺细胞的存活。
Cell Microbiol. 2010 Jan;12(1):42-54. doi: 10.1111/j.1462-5822.2009.01377.x. Epub 2009 Sep 2.
Zotero 插件