Clerget-Darpoux F, Babron M C
Unité de Recherches de Génétique Epidémiologique (INSERM U155), Paris, France.
Genet Epidemiol. 1989;6(1):59-64. doi: 10.1002/gepi.1370060112.
The MASC method has been applied to the GAW5 data. The method uses the simultaneous information on association and segregation of the HLA marker with the disease and the segregation of the HLA marker in affected families. It also takes into account the differential risk for parents of a patient, as well as the different HLA haplotype sharing, according to the HLA genotype of the patient. The goodness of fit of several genetic models has been tested. The observed data are not compatible with a two-allele, one-locus model, but they fit a three-allele, one-locus model and a complementation two-locus model if additional familial correlation is allowed.
MASC方法已应用于GAW5数据。该方法利用了HLA标记与疾病的关联和分离以及受影响家庭中HLA标记的分离的同时信息。它还考虑了患者父母的不同风险，以及根据患者的HLA基因型不同的HLA单倍型共享情况。已经测试了几种遗传模型的拟合优度。观察到的数据与双等位基因、单基因座模型不相符，但如果允许额外的家族相关性，则符合三等位基因、单基因座模型和互补双基因座模型。
