Li L I, Tang Liling
College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Curr Pharm Des. 2015;21(21):3041-50. doi: 10.2174/1381612821666150212155239.
It is necessary to use more effective and safer therapies to treat the increasing prevalence of metabolic diseases. The evidence from several studies indicates that FGF21 which acts as an endocrine hormone can induce beneficial influence to metabolism without apparent adverse effects. Thus, the pharmacologic and physiologic actions of FGF21 play a key role in controlling substrate utilization and energy balance. Recently, the developments in the understanding of FGF21 have contributed to make FGF21 a viable and promising therapeutic agent. This review discusses the functions of FGF21 in the high-fat-diet response, the relationship between exercise and the expression of FGF21, the interaction between FGF21 and some important hormone, the potential of FGF21 pharmacology in human and the methods to prolong the half-life of FGF21. These perspectives about FGF21's therapeutic potential highlight the importance of this molecule which could be a novel and attractive drug for metabolism disorder.
有必要使用更有效、更安全的疗法来治疗日益普遍的代谢性疾病。多项研究的证据表明，作为一种内分泌激素的成纤维细胞生长因子21（FGF21）可对代谢产生有益影响，且无明显不良反应。因此，FGF21的药理和生理作用在控制底物利用和能量平衡方面起着关键作用。最近，对FGF21认识的进展促使其成为一种可行且有前景的治疗药物。本文综述了FGF21在高脂饮食反应中的功能、运动与FGF21表达之间的关系、FGF21与一些重要激素之间的相互作用、FGF21在人体中的药理学潜力以及延长FGF21半衰期的方法。这些关于FGF21治疗潜力的观点凸显了该分子的重要性，它可能成为治疗代谢紊乱的一种新型且有吸引力的药物。
