Tomas-Carus P, Ortega-Alonso A, Pietiläinen K H, Santos V, Gonçalves Gonçalves, H H, Ramos J, Raimundo A
Department of Sport and Health, Universidade de Évora, Évora, Portugal -
J Sports Med Phys Fitness. 2015 Feb 12.
to evaluate the effects of a 12--weeks combined aerobic--resistance exercise therapy on fatigue and isokinetic muscle strength, glycemic control and health--related quality of life (HRQoL) in moderately affected type 2 diabetes (T2DM) patients.
a randomized controlled trial design was employed. Forty--three T2DM patients were assigned to an exercise group (n = 22), performing 3 weekly sessions of 60 minutes of combined aerobic--resistance exercise for 12--weeks; or a no exercise control group (n = 21). Both groups were evaluated at a baseline and after 12--weeks of exercise therapy for: 1) muscle strength and fatigue by isokinetic dynamometry; 2) plasma glycated hemoglobin A1C (HbA1C); and 3) HRQoL utilizing the SF--36 questionnaire.
the exercise therapy led to improvements in muscle fatigue in knee extensors (--55%) and increased muscle strength in knee flexors and extensors (+15 to +30%), while HbA1C decreased (--18%). In addition, the exercising patients showed sizeable improvements in HRQoL: physical function (+53%), vitality (+21%) and mental health (+40%).
12--weeks of combined aerobic--resistance exercise was highly effective to improve muscle strength and fatigue, glycemic control and several aspects of HRQoL in T2DM patients. These data encourage the use of aerobic and resistance exercise in the good clinical care of T2DM.
评估为期12周的有氧运动与抗阻运动联合疗法对中度2型糖尿病（T2DM）患者疲劳、等速肌力、血糖控制及健康相关生活质量（HRQoL）的影响。
采用随机对照试验设计。43例T2DM患者被分配至运动组（n = 22），进行为期12周、每周3次、每次60分钟的有氧运动与抗阻运动联合训练；或不运动的对照组（n = 21）。两组均在基线期及运动治疗12周后进行评估，内容包括：1）通过等速测力法评估肌肉力量和疲劳；2）检测血浆糖化血红蛋白A1C（HbA1C）；3）使用SF-36问卷评估HRQoL。
运动疗法使膝伸肌的肌肉疲劳得到改善（-55%），膝屈肌和膝伸肌的肌肉力量增加（+15%至+30%），同时HbA1C降低（-18%）。此外，运动组患者的HRQoL有显著改善：身体功能（+53%）、活力（+21%）和心理健康（+40%）。
为期12周的有氧运动与抗阻运动联合疗法对改善T2DM患者的肌肉力量和疲劳、血糖控制及HRQoL的多个方面非常有效。这些数据支持在T2DM的良好临床护理中使用有氧运动和抗阻运动。
