日本患者中补体等位基因C4AQ0和C4B5与类风湿性关节炎的关联
Association of complement alleles C4AQ0 and C4B5 with rheumatoid arthritis in Japanese patients.
作者信息
Takeuchi F, Mimori A, Matsuta K, Nakano K, Miyamoto T, Matsuki K, Juji T, Maeda H, Omoto K, Tokunaga K
机构信息
Department of Medicine, Faculty of Medicine, University of Tokyo, Japan.
出版信息
Arthritis Rheum. 1989 Jun;32(6):691-8. doi: 10.1002/anr.1780320606.
We investigated polymorphisms of complement components C2, C4, and factor B (BF) in Japanese patients with rheumatoid arthritis (RA). The frequencies of C4AQ0 (32.1%) and C4B5 (35.9%) among RA patients were significantly higher than among healthy control subjects. C4B5 was strongly associated with HLA-Bw54, Bw59, DR4.1, and DQw4. C4AQ0 showed no association with HLA-Bw54 or Bw59, but there was weak association with HLA-DR4.1 and DQw4. The number of persons with both C4AQ0 and C4B5 was significantly higher in the RA patient group (relative risk 13.5). C2C and BFS were the most common alleles in RA patients, as well as in healthy control subjects. These data support the existence of 2 different putative susceptibility haplotypes (HLA-Bw54 or Bw59;C2C; BFS;C4A3;C4B5;DR4.1;DQw4 and C2C;BFS; C4AQ0;C4B1 or C4B2) in Japanese patients with RA.
我们研究了日本类风湿关节炎（RA）患者补体成分C2、C4和B因子（BF）的多态性。RA患者中C4AQ0（32.1%）和C4B5（35.9%）的频率显著高于健康对照者。C4B5与HLA - Bw54、Bw59、DR4.1和DQw4密切相关。C4AQ0与HLA - Bw54或Bw59无关联，但与HLA - DR4.1和DQw4存在弱关联。RA患者组中同时具有C4AQ0和C4B5的人数显著更高（相对风险13.5）。C2C和BFS是RA患者以及健康对照者中最常见的等位基因。这些数据支持在日本RA患者中存在两种不同的假定易感单倍型（HLA - Bw54或Bw59；C2C；BFS；C4A3；C4B5；DR4.1；DQw4以及C2C；BFS；C4AQ0；C4B1或C4B2）。
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