韩国人中补体等位基因C4AQ0和C4B5与类风湿性关节炎的关联。
Association of complement alleles C4AQ0 and C4B5 with rheumatoid arthritis in Koreans.
作者信息
Park M H, Oh M D, Song Y W, Pai H J, Takeuchi F, Tokunaga K, Hong G H, Park K S
机构信息
Department of Clinical Pathology, Seoul National University College of Medicine, Korea.
出版信息
Ann Rheum Dis. 1996 Oct;55(10):776-8. doi: 10.1136/ard.55.10.776.
OBJECTIVE
To investigate the association of complement C4 allotypes with rheumatoid arthritis in Koreans.
METHODS
65 rheumatoid arthritis patients and 255 controls were typed for C4 allotypes and HLA-A, B, C, DR, and DQ antigens.
RESULTS
The frequencies of C4AQ0 (32.3% v 14.9%, P < 0.005) and C4B5 (29.2% v 12.2%, P < 0.005) were significantly increased in rheumatoid arthritis patients compared with healthy control subjects. Among rheumatoid patients, the frequency of C4AQ0 was significantly increased in both the rheumatoid factor (RF) positive (27.3%) and the RF negative (66.7%) subgroups. The frequencies of C4B5 and HLA-DR4 were significantly increased only in RF positive subgroup. C4B5 was strongly associated with HLA-DR4, whereas C4AQ0 did not show association with DR4.
CONCLUSIONS
In Koreans, C4AQ0 and C4B5 are associated with susceptibility to rheumatoid arthritis, as in the Japanese. C4B5 is strongly associated with HLA-DR4. C4AQ0 is considered to be a DR4 independent risk factor, and a disease susceptibility allele in linkage disequilibrium with C4AQ0 is suggested in Korean patients with rheumatoid arthritis.
目的
研究韩国人中补体C4别型与类风湿关节炎的关联。
方法
对65例类风湿关节炎患者和255例对照进行C4别型以及HLA - A、B、C、DR和DQ抗原分型。
结果
与健康对照相比，类风湿关节炎患者中C4AQ0（32.3%对14.9%，P < 0.005）和C4B5（29.2%对12.2%，P < 0.005）的频率显著增加。在类风湿患者中，C4AQ0频率在类风湿因子（RF）阳性（27.3%）和RF阴性（66.7%）亚组中均显著增加。C4B5和HLA - DR4频率仅在RF阳性亚组中显著增加。C4B5与HLA - DR4强相关，而C4AQ0与DR4无关联。
结论
在韩国人中C与日本人一样，C4AQ0和C4B5与类风湿关节炎易感性相关。C4B5与HLA - DR4强相关。C4AQ0被认为是一个独立于DR4的危险因素，并且提示在韩国类风湿关节炎患者中存在与C4AQ0处于连锁不平衡状态的疾病易感性等位基因。
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