Park M H, Oh M D, Song Y W, Pai H J, Takeuchi F, Tokunaga K, Hong G H, Park K S
Department of Clinical Pathology, Seoul National University College of Medicine, Korea.
Ann Rheum Dis. 1996 Oct;55(10):776-8. doi: 10.1136/ard.55.10.776.
To investigate the association of complement C4 allotypes with rheumatoid arthritis in Koreans.
65 rheumatoid arthritis patients and 255 controls were typed for C4 allotypes and HLA-A, B, C, DR, and DQ antigens.
The frequencies of C4AQ0 (32.3% v 14.9%, P < 0.005) and C4B5 (29.2% v 12.2%, P < 0.005) were significantly increased in rheumatoid arthritis patients compared with healthy control subjects. Among rheumatoid patients, the frequency of C4AQ0 was significantly increased in both the rheumatoid factor (RF) positive (27.3%) and the RF negative (66.7%) subgroups. The frequencies of C4B5 and HLA-DR4 were significantly increased only in RF positive subgroup. C4B5 was strongly associated with HLA-DR4, whereas C4AQ0 did not show association with DR4.
In Koreans, C4AQ0 and C4B5 are associated with susceptibility to rheumatoid arthritis, as in the Japanese. C4B5 is strongly associated with HLA-DR4. C4AQ0 is considered to be a DR4 independent risk factor, and a disease susceptibility allele in linkage disequilibrium with C4AQ0 is suggested in Korean patients with rheumatoid arthritis.
研究韩国人中补体C4别型与类风湿关节炎的关联。
对65例类风湿关节炎患者和255例对照进行C4别型以及HLA - A、B、C、DR和DQ抗原分型。
与健康对照相比，类风湿关节炎患者中C4AQ0（32.3%对14.9%，P < 0.005）和C4B5（29.2%对12.2%，P < 0.005）的频率显著增加。在类风湿患者中，C4AQ0频率在类风湿因子（RF）阳性（27.3%）和RF阴性（66.7%）亚组中均显著增加。C4B5和HLA - DR4频率仅在RF阳性亚组中显著增加。C4B5与HLA - DR4强相关，而C4AQ0与DR4无关联。
在韩国人中C与日本人一样，C4AQ0和C4B5与类风湿关节炎易感性相关。C4B5与HLA - DR4强相关。C4AQ0被认为是一个独立于DR4的危险因素，并且提示在韩国类风湿关节炎患者中存在与C4AQ0处于连锁不平衡状态的疾病易感性等位基因。
