Schnorr Carlos Eduardo, Bittencourt Leonardo da Silva, Petiz Lyvia Lintzmaier, Gelain Daniel Pens, Zeidán-Chuliá Fares, Moreira José Cláudio Fonseca
Centro de Estudos de Estresse Oxidativo, Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Mol Nutr Food Res. 2015 May;59(5):979-90. doi: 10.1002/mnfr.201400637. Epub 2015 Mar 23.
Aging process makes older adults especially vulnerable to neurodegeneration and mental disorders. Overconsumption-related neurotoxic effects of certain dietary nutrients by older population could represent a contribution factor for the development of neuropsychiatric conditions by this subpopulation. Thus, we here investigated whether chronic supplementation with retinyl palmitate, at doses commonly found in vitamin supplements (300, 600, and 3000 mcg of RAE/kg/day), could have an impact on emotional behavior of middle-aged Wistar rats.
We report that supplementation with retinyl palmitate for 28 days induces an altered emotional state of middle-aged Wistar rats and oxidative stress in cerebellum, cerebral cortex, hippocampus, and striatum, associated with imbalance of enzymatic antioxidant defenses, decrease in non-enzymatic antioxidant defenses, and increase in protein and lipid damages.
Our data show evidence for (i) changes in emotional reactivity, similar to anxiety, in middle-aged rats chronically supplemented with retinyl palmitate; and (ii) suggest a possible interrelation between pro-oxidant events in the brain and these differences in the behavioral profile that cannot be attributed to hepatotoxicity. Our results invite for additional studies to further investigate such interrelation.
衰老过程使老年人特别容易患神经退行性疾病和精神障碍。老年人群中某些膳食营养素的过度摄入相关神经毒性作用可能是该亚群神经精神疾病发展的一个促成因素。因此，我们在此研究了以维生素补充剂中常见剂量（300、600和3000微克视黄醇活性当量/千克/天）长期补充棕榈酸视黄酯是否会对中年Wistar大鼠的情绪行为产生影响。
我们报告称，补充棕榈酸视黄酯28天会导致中年Wistar大鼠情绪状态改变，并在小脑、大脑皮层、海马体和纹状体中引发氧化应激，这与酶促抗氧化防御失衡、非酶促抗氧化防御减少以及蛋白质和脂质损伤增加有关。
我们的数据表明：（i）长期补充棕榈酸视黄酯的中年大鼠情绪反应发生变化，类似于焦虑；（ii）提示大脑中的促氧化事件与行为特征的这些差异之间可能存在相互关系，而这些差异不能归因于肝毒性。我们的结果促使进行更多研究以进一步探究这种相互关系。
