Infection Control, Singapore General Hospital, Singapore.
Division of Infectious Diseases, Thammasat University Hospital, Pratumthani, Thailand.
Clin Infect Dis. 2015 Jun 1;60(11):1690-9. doi: 10.1093/cid/civ095. Epub 2015 Feb 12.
A systematic literature review and meta-analysis of the burden of healthcare-associated infections (HAIs) in Southeast Asia was performed on 41 studies out of the initially identified 14 089 records. The pooled prevalence of overall HAIs was 9.0% (95% confidence interval [CI], 7.2%-10.8%), whereas the pooled incidence density of HAI was 20 cases per 1000 intensive care unit-days. The pooled incidence density of ventilator-associated pneumonia, central line-associated bloodstream infection, and catheter-associated urinary tract infection was 14.7 per 1000 ventilator-days (95% CI, 11.7-17.7), 4.7 per 1000 catheter-days (95% CI, 2.9-6.5), and 8.9 per 1000 catheter-days (95% CI, 6.2-11.7), respectively. The pooled incidence of surgical site infection was 7.8% (95% CI, 6.3%-9.3%). The attributed mortality and excess length of stay in hospitals of infected patients ranged from 7% to 46% and 5 to 21 days, respectively.
对最初确定的 14089 条记录中的 41 项研究进行了系统的文献回顾和东南亚医疗保健相关感染（HAI）负担的荟萃分析。总体 HAI 的 pooled 患病率为 9.0%（95%置信区间[CI]，7.2%-10.8%），而 HAI 的 pooled 发病率密度为每 1000 个重症监护病房日 20 例。呼吸机相关性肺炎、中心静脉导管相关血流感染和导管相关尿路感染的 pooled 发病率密度分别为每 1000 个呼吸机日 14.7 例（95%CI，11.7-17.7）、每 1000 个导管日 4.7 例（95%CI，2.9-6.5）和每 1000 个导管日 8.9 例（95%CI，6.2-11.7）。手术部位感染的 pooled 发病率为 7.8%（95%CI，6.3%-9.3%）。感染患者的归因死亡率和医院超额住院时间范围为 7%至 46%和 5 至 21 天。
