OASL——控制抗病毒天然免疫的新角色。
OASL-a new player in controlling antiviral innate immunity.
作者信息
Zhu Jianzhong, Ghosh Arundhati, Sarkar Saumendra N
机构信息
Cancer Virology Program, University of Pittsburgh Cancer Institute, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Cancer Virology Program, University of Pittsburgh Cancer Institute, United States; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
出版信息
Curr Opin Virol. 2015 Jun;12:15-9. doi: 10.1016/j.coviro.2015.01.010. Epub 2015 Feb 9.
Abstract
The cellular innate immune system plays a crucial role in mounting the initial resistance to virus infection. It is comprised of various pattern-recognition receptors that induce type I interferon production, which further shapes the adaptive immunity. However, to overcome this resistance and promote replication, viruses have evolved mechanisms to evade this host innate immune response. Here we discuss a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like (OASL) protein, which can potentially be used to overcome viral evasion and enhance innate immunity.
摘要
细胞先天性免疫系统在对病毒感染产生初始抗性方面发挥着关键作用。它由多种诱导I型干扰素产生的模式识别受体组成，而I型干扰素进一步塑造适应性免疫。然而，为了克服这种抗性并促进复制，病毒已经进化出逃避宿主先天性免疫反应的机制。在此，我们讨论一种最近描述的由寡腺苷酸合成酶样（OASL）蛋白增强先天性免疫的机制，该机制可能用于克服病毒逃避并增强先天性免疫。
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