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类寡腺苷酸合成酶蛋白是什么，它对流感有治疗潜力吗？

What is the oligoadenylate synthetases-like protein and does it have therapeutic potential for influenza?

作者信息

Alcorn John F, Sarkar Saumendra N

机构信息

Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

出版信息

Expert Rev Respir Med. 2015 Feb;9(1):1-3. doi: 10.1586/17476348.2015.994608. Epub 2014 Dec 29.

DOI:10.1586/17476348.2015.994608
PMID:25544107
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4629247/
Abstract

Besides its pandemic potential, seasonal influenza infection is associated with an estimated 250,000 to 500,000 deaths worldwide every year. Part of this virulence of influenza virus can be attributed to its ability to evade the host innate immune response. Here, we discuss the possibility of using a recently described mechanism of boosting the innate immunity by oligoadenylate synthetase-like protein, to combat influenza infections.

摘要

除了具有大流行的可能性外，季节性流感感染每年在全球估计导致25万至50万人死亡。流感病毒的这种毒力部分可归因于其逃避宿主先天免疫反应的能力。在此，我们讨论利用一种最近描述的由寡腺苷酸合成酶样蛋白增强先天免疫的机制来对抗流感感染的可能性。

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本文引用的文献

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Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor.人 OASL 蛋白的抗病毒活性是通过增强 RIG-I RNA 传感器的信号转导来介导的。
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