Zhang Xiang, Yang Chao, Zhang-Negrerie Daisy, Du Yunfei
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072 (China), Fax: (+86) 22-2740-4031.
Chemistry. 2015 Mar 23;21(13):5193-8. doi: 10.1002/chem.201406393. Epub 2015 Feb 9.
An unusual reaction featuring the cascade annulation of internal alkynes to afford spiro heterocycles as the products has been realized for the first time with a hypervalent iodine reagent as the only oxidant. This unprecedented process encompasses not only two sequential C-N/C-O-bond formations, but also the insertion of a carbonyl oxygen, all in one pot under metal-free conditions.
首次实现了一种不寻常的反应，以高价碘试剂作为唯一氧化剂，使内炔烃发生串联环化反应生成螺杂环产物。这一前所未有的过程不仅包括两个连续的C-N/C-O键形成，还包括羰基氧的插入，所有这些反应均在无金属条件下一步完成。
