Dowell Joshua D, Mukherjee Sugoto, Raghavan Prashant, Rehm Patrice K
Department of Radiology, Ohio State University Medical Center, Columbus, OH.
Department of Radiology & Medical Imaging, University of Virginia Health System, Charlottesville, VA.
J Neuroimaging. 2015 Nov-Dec;25(6):1047-9. doi: 10.1111/jon.12212. Epub 2015 Feb 10.
Granulomatous amebic encephalitis (GAE) is a rare and oftentimes fatal disease in immune compromised patients caused by free living amebae Acanthamoeba and Balamuthia. We report a patient in whom GAE secondary to Acanthamoeba was the initial presentation of acquired immunodeficiency syndrome in a 41-year-old male, and discuss the FDG positron emission tomography (PET) and magnetic resonance imaging findings that preceded the pathological diagnosis. The PET results provided complementary information when coupled with the MR brain findings. Improved understanding of the clinical and imaging findings of this deadly disease is the best hope for early diagnosis and treatment of this uncommon but deadly disease.
肉芽肿性阿米巴脑炎（GAE）是一种在免疫功能低下患者中罕见且往往致命的疾病，由自由生活的阿米巴原虫棘阿米巴属和巴拉姆希阿米巴引起。我们报告了一名41岁男性患者，其继发于棘阿米巴的GAE是获得性免疫缺陷综合征的首发表现，并讨论了在病理诊断之前的氟代脱氧葡萄糖正电子发射断层扫描（PET）和磁共振成像结果。PET结果与脑部磁共振成像结果相结合时提供了补充信息。更好地了解这种致命疾病的临床和影像学表现是早期诊断和治疗这种罕见但致命疾病的最大希望。
