一名人类免疫缺陷病毒阳性男性发生肉芽肿性棘阿米巴脑炎的致死病例报告
Lethal outcome of granulomatous acanthamoebic encephalitis in a man who was human immunodeficiency virus-positive: a case report.
作者信息
Geith Stefanie, Walochnik Julia, Prantl Franz, Sack Stefan, Eyer Florian
机构信息
Division of Clinical Toxicology & Poison Control Centre Munich, Department of Internal Medicine II, TUM School of Medicine, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
Medical University of Vienna, Center for Pathophysiology, Infectiology and Immunology, Institute of Specific Prophylaxis and Tropical Medicine, Kinderspitalgasse 15, 1090, Vienna, Austria.
出版信息
J Med Case Rep. 2018 Jul 12;12(1):201. doi: 10.1186/s13256-018-1734-8.
BACKGROUND
Acanthamoeba species can cause disseminating infections in immunocompromised individuals.
CASE PRESENTATION
Here, we report a case of granulomatous acanthamoebic encephalitis with a lethal outcome in a 54-year-old German man who was human immunodeficiency virus-positive. The diagnosis was based on symptoms of progressive neurological deficits, including sensorimotor paralysis of his right leg and deteriorating alertness. Due to the rapid course and rather late diagnosis of the infection, effective treatment could not be applied and he died 12 days after hospital admission.
CONCLUSIONS
To the best of our knowledge, this is the second case of granulomatous acanthamoebic encephalitis reported within Germany. Our case highlights the importance of early diagnosis of granulomatous acanthamoebic encephalitis to prevent fatal outcome.
背景
棘阿米巴属可在免疫功能低下个体中引起播散性感染。
病例报告
在此，我们报告一例肉芽肿性棘阿米巴脑炎病例，一名54岁的德国男性，人类免疫缺陷病毒阳性，最终死亡。诊断基于进行性神经功能缺损症状，包括右腿感觉运动麻痹和意识水平恶化。由于感染病程进展迅速且诊断较晚，无法进行有效治疗，患者入院12天后死亡。
结论
据我们所知，这是德国境内报告的第二例肉芽肿性棘阿米巴脑炎病例。我们的病例强调了早期诊断肉芽肿性棘阿米巴脑炎以预防致命后果的重要性。
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