Ma Guoda, Wang Yajun, Li You, Cui Lili, Zhao Yujuan, Zhao Bin, Li Keshen
1. Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China; ; 2. Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China;
3. Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China;
Int J Biol Sci. 2015 Feb 5;11(3):345-52. doi: 10.7150/ijbs.10921. eCollection 2015.
MicroRNAs (miRNAs) have recently emerged as fundamental post-transcriptional regulators inhibit gene expression linked to various biological processes. MiR-206 is one of the most studied and best characterized miRNA to date, which specifically expressed in skeletal muscle. In this review, we summarized the results of studies of miR-206 with emphasis on its function in skeletal muscle development. Importantly, dysregulation of miR-206 has been linked to many disorders in skeletal muscle such as Duchenne muscular dystrophy (DMD) and amyotrophic lateral sclerosis (ALS), and circulating miR-206 has highlighted its potential as a diagnose biomarker. In addition, a mutation in the 3' untranslated region (3'-UTR) of the myostatin gene in the Texel sheep creating a target site for the miR-206 and miR-1 leads to inhibition of myostatin expression, which likely to cause the muscular hypertrophy phenotype of this breed of sheep. Therefore, miR-206 may become novel target for ameliorating skeletal muscle-related disorders and optimization of muscle quantity of domestic animals.
微小RNA（miRNA）最近已成为抑制与各种生物过程相关的基因表达的基本转录后调节因子。miR-206是迄今为止研究最多、特征最明确的miRNA之一，它在骨骼肌中特异性表达。在这篇综述中，我们总结了miR-206的研究结果，重点关注其在骨骼肌发育中的功能。重要的是，miR-206的失调与骨骼肌中的许多疾病有关，如杜氏肌营养不良症（DMD）和肌萎缩侧索硬化症（ALS），并且循环miR-206突出了其作为诊断生物标志物的潜力。此外，特克塞尔羊肌生成抑制素基因3'非翻译区（3'-UTR）的一个突变产生了miR-206和miR-1的靶位点，导致肌生成抑制素表达受到抑制，这可能导致该品种绵羊的肌肉肥大表型。因此，miR-206可能成为改善骨骼肌相关疾病和优化家畜肌肉量的新靶点。
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