Foster P S, Gesini E, Claudianos C, Hopkinson K C, Denborough M A
Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra A.C.T.
Lancet. 1989 Jul 15;2(8655):124-7. doi: 10.1016/s0140-6736(89)90182-7.
The sarcoplasmic reticulum from muscle of swine which are susceptible to malignant hyperpyrexia is deficient in inositol 1,4,5-trisphosphate phosphatase (InsP35-ase) activity, which leads to high intracellular concentrations of inositol 1,4,5-trisphosphate (InsP3) and of calcium ions. Halothane inhibits InsP35-ase and further increases myoplasmic InsP3 and calcium ion concentrations, and produces the clinical features of malignant hyperpyrexia.
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