肌醇1,4,5-三磷酸：肌肉兴奋-收缩偶联中可能的化学联系。
Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.
作者信息
Vergara J, Tsien R Y, Delay M
出版信息
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6352-6. doi: 10.1073/pnas.82.18.6352.
Abstract
The role of inositol 1,4,5-trisphosphate (InsP3) in excitation-contraction coupling in skeletal muscle was investigated by several methods. The following results were obtained. InsP3 is released by electrical stimulation of muscles. Exogenous InsP3 releases calcium from skinned muscle fibers at relatively high doses under normal conditions but does so at very low concentrations when blockers of the InsP3 5-phosphatase are present. Blockers of InsP3 release are effective blockers of calcium transients elicited by electrical stimulation of muscle fibers. It is proposed that InsP3 acts as a chemical second messenger between transverse (T)-tubular membrane depolarization and calcium release from the sarcoplasmic reticulum in skeletal muscle.
摘要
通过多种方法研究了肌醇 1,4,5 - 三磷酸（InsP3）在骨骼肌兴奋 - 收缩偶联中的作用。得到了以下结果。电刺激肌肉可释放 InsP3。在正常条件下，外源性 InsP3 在相对高剂量时可从去表皮肌纤维中释放钙，但当存在 InsP3 5 - 磷酸酶抑制剂时，在非常低的浓度下就能释放钙。InsP3 释放抑制剂是电刺激肌纤维引发的钙瞬变的有效抑制剂。有人提出，InsP3 在骨骼肌横（T）管膜去极化与肌浆网钙释放之间充当化学第二信使。
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Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.肌醇1,4,5-三磷酸：肌肉兴奋-收缩偶联中可能的化学联系。
Proc Natl Acad Sci U S A. 1985 Sep;82(18):6352-6. doi: 10.1073/pnas.82.18.6352.
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