氟烷对猪恶性高热中腺苷酸激酶的影响。

Effect of halothane on adenylate kinase in porcine malignant hyperpyrexia.

作者信息

Marjanen L A, Denborough M A

出版信息

Clin Chim Acta. 1982 Jul 1;122(2):225-30. doi: 10.1016/0009-8981(82)90281-9.

Abstract

The effects of halothane on adenylate kinase activity in porcine muscle have been examined. No abnormality in malignant hyperpyrexia susceptible muscle was found. At clinical concentrations of halothane only slight inhibition of adenylate kinase activity was observed. The inhibition increased with increasing concentrations of halothane and with decreasing concentrations of the substrates AMP or ADP. The inhibition was similar in both malignant hyperpyrexia susceptible and control muscle. It seems unlikely that adenylate kinase is involved directly in triggering malignant hyperpyrexia.

摘要

已研究了氟烷对猪肌肉中腺苷酸激酶活性的影响。未发现恶性高热易感肌肉有异常。在氟烷的临床浓度下，仅观察到腺苷酸激酶活性有轻微抑制。随着氟烷浓度的增加以及底物AMP或ADP浓度的降低，抑制作用增强。在恶性高热易感肌肉和对照肌肉中，抑制作用相似。腺苷酸激酶似乎不太可能直接参与引发恶性高热。