Doudkani-Fard Mina, Ziaee Vahid, Moradinejad Mohamad-Hassan, Sedaghat Mojtaba, Haghi-Ashtiani Mohammad-Taghi, Ahmadinejad Zahra
1. MD, Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
2. MD, Pediatric Rheumatology Research Group, Rheumatology Research Center, Tehran University of Medical Sciences and Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2014 Oct 15;28:113. eCollection 2014.
Juvenile Idiopathic Arthritis (JIA) is one of the most common chronic rheumatic diseases inchildren with unknown etiology and pathogenesis. It also has no diagnostic test and its clinical diagnosis ismade through ruling out other types of arthritis. The aim of this study was to evaluate the level of ADA (AdenosineDeaminase) in the serum of JIA patients and to compare it with that of patients with Reactive Arthritis(RA). Evaluation of sensitivity and specificity of serum ADA level in JIA was another objective.
The study included 120 children with JIA (mean age= 7.6 ± 4.3 years) and 40 children with RA(mean age= 5.5 ± 3.1 years). The ADA was measured in the active phase of both diseases.
The mean ADA serum level was obtained as 15.8 ± 11.8 U/l in JIA patients and 14.3 ± 7.5 U/l in RApatients. The difference was statistically insignificant (p= 0.4). Another finding of this study was the significantspecificity (77.5%) of this laboratory parameter for JIA in comparison with its low sensitivity (36.7%). Positivepredictive value was 83% and negative predictive value 29%.
Determination of ADA serum levels is a noninvasive reliable and easy biomarker for diagnosis ofJIA and it can be used as alternative parameters representing disease activity.
幼年特发性关节炎（JIA）是儿童中最常见的慢性风湿性疾病之一，其病因和发病机制不明。它也没有诊断性检查，临床诊断是通过排除其他类型的关节炎来做出的。本研究的目的是评估JIA患者血清中腺苷脱氨酶（ADA）的水平，并将其与反应性关节炎（ReA）患者的水平进行比较。评估血清ADA水平在JIA中的敏感性和特异性是另一个目标。
该研究纳入了120例JIA儿童（平均年龄 = 7.6 ± 4.3岁）和40例ReA儿童（平均年龄 = 5.5 ± 3.1岁）。在两种疾病的活动期测量ADA。
JIA患者的平均血清ADA水平为15.8 ± 11.8 U/l，ReA患者为14.3 ± 7.5 U/l。差异无统计学意义（p = 0.4）。本研究的另一个发现是，该实验室参数对JIA具有显著的特异性（77.5%），而敏感性较低（36.7%）。阳性预测值为83%，阴性预测值为29%。
测定血清ADA水平是诊断JIA的一种无创、可靠且简便的生物标志物，可作为代表疾病活动的替代参数。
