Tang M, Kuribara H, Falk J L
Department of Psychology, Rutgers University, New Brunswick, NJ 08903.
Pharmacol Biochem Behav. 1989 Mar;32(3):773-6. doi: 10.1016/0091-3057(89)90032-4.
The administration of drugs with anxiolytic action to rehydrating rats augments the intake of 1.5% NaCl solution. In order to clarify the status of caffeine as an anxiolytic agent and its possible interaction with a benzodiazepine having high potency and efficacy in this regard, caffeine (0.78-100 mg/kg) alone and caffeine (0.78-50 mg/kg) plus clonazepam (0.05 or 0.50 mg/kg) injections (IP) were administered to rehydrating rats prior to 1-hr sessions during which they drank 1.5% NaCl solution. When given alone, caffeine, within a particular dose range, and clonazepam at both doses, augmented NaCl solution intake, but when administered in combination, caffeine antagonized the effects of clonazepam.
给补液大鼠施用具有抗焦虑作用的药物会增加其对1.5%氯化钠溶液的摄入量。为了阐明咖啡因作为抗焦虑剂的状态及其与在这方面具有高效力和功效的苯二氮䓬类药物可能的相互作用，在1小时的时间段内，在补液大鼠饮用1.5%氯化钠溶液之前，单独注射咖啡因（0.78 - 100毫克/千克）以及注射咖啡因（0.78 - 50毫克/千克）加氯硝西泮（0.05或0.50毫克/千克）（腹腔注射）。单独给予时，在特定剂量范围内的咖啡因以及两种剂量的氯硝西泮均增加了氯化钠溶液的摄入量，但联合给药时，咖啡因拮抗了氯硝西泮的作用。
