Nadal R A, Pallares M A, Ferre N S
Area de Psicobiologia, Facultat de Psicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Physiol Behav. 1995 Jan;57(1):113-6. doi: 10.1016/0031-9384(94)00202-g.
Previous reports indicate that several anxiolytics enhance the intake of hypertonic saline in rehydrating rats. This experiment was conducted to determine the effects of repeated (5 sessions) injection (i.p.) of ethanol (0.4 or 0.8 g/kg), caffeine (20 or 40 mg/kg) or clorazepate (3 mg/kg) on the ingestion of hypertonic saline (1.8%) in water-deprived rats. Saline intake increased with the acute administration of both clorazepate and ethanol (two doses), but it decreased with caffeine (two doses). It seems that the increase or decrease of hypertonic saline ingestion following acute drug administration continues to correlate well with anxiolytic or anxiogenic actions. However, following repeated administration of caffeine and ethanol, the effects on saline intake were not maintained in a reliable manner.
先前的报告表明，几种抗焦虑药会增加补液大鼠的高渗盐水摄入量。本实验旨在确定对缺水大鼠反复（5次）腹腔注射乙醇（0.4或0.8克/千克）、咖啡因（20或40毫克/千克）或氯氮卓（3毫克/千克）对其摄入1.8%高渗盐水的影响。氯氮卓和两种剂量的乙醇急性给药后，盐水摄入量增加，但咖啡因（两种剂量）给药后则减少。急性给药后高渗盐水摄入量的增加或减少似乎仍与抗焦虑或致焦虑作用密切相关。然而，咖啡因和乙醇反复给药后，对盐水摄入量的影响未能可靠维持。
