Haro Márquez Carmen, Cantudo Cuenca Maria Rosa, Almeida González Carmen Victoria, Morillo Verdugo Ramón
Farmacéutica residente. UGC de Farmacia, Área de Gestión Sanitaria Sur de Sevilla, Carretera de Cádiz S/N, 41014, Sevilla, España..
Bioestadística, Área de Gestión Sanitaria Sur de Sevilla. Prof. Asociada,Universidad de Sevilla. Carretera de Cádiz S/N, 41014, Sevilla, España..
Farm Hosp. 2015 Jan 1;39(1):23-8. doi: 10.7399/fh.2015.39.1.8127.
To assess adherence and beliefs about long-term medicines for other chronic conditions among HIV-infected patients as well as to evaluate their relationship.
A cross-sectional study was conducted from may to july 2014 in HIV-infected patients treated with antiretroviral treatment (ART) and ≥1 long-term medicines for other chronic diseases. The variables analysed in the study were demographics: sex, age, education, employment status, living situation; clinical: mode of transmission, HIV plasma viral load, T-CD4+, CDC classification; and pharmacotherapeutics: type of ART, adherence to long-term medicines for other chronic conditions using the 4-item Morisky Medication Adherence (MMAS) Scale. MMAS scores were dichotomised into adherent/non-adherent. The Beliefs about Medicines Questionnaires (BMQ) was used to assess patients' beliefs about the long-term medicines. The BMQ-Specific has two scales (necessity and concern) with five questions each that uses a 5-point Likert scale. Internal consistency within BMQ scales was measured with Cronbach's α and their association with adherence was assessed with t-Student tests, using SPSS 20.0.
We included 126 patients (80.4% male, mean age 49.0 ± 8.3). The mean of long-term medicines was 2.9 ± 2.0. The percentage of non-adherent patients was 54.0%. 63.5% of patients had AIDS, that showed statistically significant relationship with non-adherence. Concerns were negatively related to self-reported adherence (14.6 ± 5.7 vs. 12.1 ± 6.1; p=0.019). No relationship between adherence and necessity was found (17.3 ± 5.6 vs. 18.8 ± 4.4; p=0.188). Internal consistency for BMQ-Specific was high (Cronbach's α=0.724).
Higher concerns are associated with higher self-reported adherence to long-term medicines in HIV infected-patients.
评估HIV感染患者对其他慢性病长期用药的依从性和信念，并评估它们之间的关系。
2014年5月至7月对接受抗逆转录病毒治疗（ART）且正在使用≥1种治疗其他慢性病的长期药物的HIV感染患者进行了一项横断面研究。研究中分析的变量包括人口统计学特征：性别、年龄、教育程度、就业状况、生活状况；临床特征：传播方式、HIV血浆病毒载量、T-CD4+、疾病控制中心（CDC）分类；以及药物治疗学特征：ART类型、使用4项Morisky药物依从性（MMAS）量表评估对其他慢性病长期药物的依从性。MMAS评分被分为依从/不依从。使用药物信念问卷（BMQ）评估患者对长期药物的信念。BMQ-特异性问卷有两个量表（必要性和担忧），每个量表有五个问题，采用5点李克特量表。使用SPSS 20.0，用Cronbach's α测量BMQ量表内部的一致性，并通过t检验评估它们与依从性的关联。
我们纳入了126例患者（80.4%为男性，平均年龄49.0±8.3岁）。长期用药的平均数为2.9±2.0种。不依从患者的比例为54.0%。63.5%的患者患有艾滋病，这与不依从存在统计学上的显著关系。担忧与自我报告的依从性呈负相关（14.6±5.7对12.1±6.1；p=0.019）。未发现依从性与必要性之间存在关系（17.3±5.6对18.8±4.4；p=0.188）。BMQ-特异性问卷的内部一致性较高（Cronbach's α=0.724）。
在HIV感染患者中，较高的担忧与较高的自我报告的长期药物依从性相关。
