Bjellerup M
Department of Dermatology, University of Lund, General Hospital, Malmö, Sweden.
Acta Derm Venereol. 1989;69(4):339-41.
Peculiar nail-changes in a 70-year-old woman with rheumatoid arthritis occurring after approximately 1 year of penicillamine treatment are described. After cessation of treatment there was a gradual resolution with regain of normal nails after 7 months. Reinstitution of penicillamine treatment caused a recurrence thus proving a causal relationship between penicillamine and the described nail-changes. The fingernails were more affected than the toenails and clinically the changes consisted of absence of lunulae, longitudinal ridging, transverse or longitudinal defects of the nailplate and a tendency of onychoschizia.
描述了一名70岁类风湿关节炎女性在接受青霉胺治疗约1年后出现的特殊指甲变化。停止治疗后，指甲逐渐恢复正常，7个月后指甲恢复正常。重新使用青霉胺治疗导致复发，从而证明青霉胺与所描述的指甲变化之间存在因果关系。手指甲比脚趾甲受影响更严重，临床上的变化包括半月痕消失、纵向嵴、甲板横向或纵向缺损以及甲裂片倾向。
