Zhao J C, Liu W Q
Shaanxi Provincial Academy of Traditional Chinese Medicine and Pharmacology, People's Republic of China.
Acupunct Electrother Res. 1989;14(1):1-7. doi: 10.3727/036012989816358533.
By injecting Naloxone, the T-lymphocyte transformation was reduced markedly. When the Naloxone plus electro-acupuncture were used together, it was not reduced but was still lower than it was when only electro-acupuncture was used. This explained why Naloxone could reverse the function by which electro-acupuncture promoted the T-lymphocyte transformation, and the endogenous opioid in the brain promoted the immune reaction. Through promoting the release of the endogenous opioid in the brain, electro-acupuncture raised the T-lymphocyte transformation function. Using electro-acupuncture when naloxone antagonized morphine, the T-lymphocyte transformation function was still promoted markedly. The mechanism could be that electro-acupuncture excited the function of the endogenous opioid system in the brain. In acupuncture immune reaction, the relationship between the endogenous opioid and catecholaminergic systems was explored.
注射纳洛酮后，T淋巴细胞转化明显降低。当纳洛酮与电针联合使用时，T淋巴细胞转化并未降低，但仍低于单纯使用电针时的水平。这解释了为何纳洛酮可逆转电针促进T淋巴细胞转化的作用，以及脑内内源性阿片肽可促进免疫反应。电针通过促进脑内内源性阿片肽的释放，提高了T淋巴细胞转化功能。在纳洛酮拮抗吗啡时使用电针，T淋巴细胞转化功能仍明显增强。其机制可能是电针兴奋了脑内的内源性阿片肽系统。在针刺免疫反应中，探讨了内源性阿片肽与儿茶酚胺能系统之间的关系。
