Prien R F, Gelenberg A J
Affective and Anxiety Disorders Research Branch, Division of Clinical Research, NIMH, Rockville, MD 20857.
Am J Psychiatry. 1989 Jul;146(7):840-8. doi: 10.1176/ajp.146.7.840.
The authors review the research literature on drug treatment for the prevention of recurrences in bipolar disorder, emphasizing the available alternatives to lithium therapy. They discuss the need for alternative treatments and the current status of promising agents. Carbamazepine receives special attention because of its status as the most promising backup treatment for lithium. The authors conclude that despite the extensive literature on carbamazepine, there is strong need for carefully designed, prospective, double-blind studies to establish the efficacy of carbamazepine alone and in combination with lithium as a prophylactic treatment for bipolar disorder. Difficulties in developing and evaluating preventive maintenance are discussed.
作者回顾了关于双相情感障碍复发预防的药物治疗研究文献，重点强调了锂盐治疗之外的可用替代方案。他们讨论了替代治疗的必要性以及有前景药物的当前状况。卡马西平因其作为锂盐最有前景的备用治疗药物的地位而受到特别关注。作者总结道，尽管关于卡马西平的文献广泛，但仍迫切需要精心设计的前瞻性双盲研究，以确定卡马西平单独使用以及与锂盐联合使用作为双相情感障碍预防性治疗的疗效。文中还讨论了开展和评估预防性维持治疗的困难。
