Yang Y Y, Deng H C, Wang B H
Department of Psychiatry, Chang Gung College of Medicine and Technology, and Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Psychiatry Clin Neurosci. 1998 Aug;52(4):429-31. doi: 10.1046/j.1440-1819.1998.00405.x.
The medical records of patents with bipolar disorders who received prophylactic drug treatments during three time periods from January 1983 to December 1984, January 1988 to December 1989, and from January 1993 to December 1994, were reviewed retrospectively. The percentage of lithium monotherapy sharply decreased from 96% (51/53) in the first study period to 51.9% (83/160) in the third study period. Carbamazepine monotherapy and combination of lithium and carbamazepine increased from 3.8% in the first study period to 45.6% in the third study period. These results suggest that anticonvulsants may become one of the major drug treatment strategies for bipolar disorder in the future.
对1983年1月至1984年12月、1988年1月至1989年12月以及1993年1月至1994年12月这三个时间段接受预防性药物治疗的双相情感障碍患者的病历进行了回顾性审查。单药使用锂盐的比例从第一个研究期的96%（51/53）急剧下降到第三个研究期的51.9%（83/160）。卡马西平单药治疗以及锂盐与卡马西平联合治疗从第一个研究期的3.8%增加到第三个研究期的45.6%。这些结果表明，抗惊厥药物未来可能成为双相情感障碍的主要药物治疗策略之一。
