Haas Paulina, Kubista Katharina E, Krugluger Walter, Huber Johannes, Binder Susanne
Department of Ophthalmology, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Lasersurgery, Rudolf Foundation Clinic, Vienna, Austria.
Department of Laboratory Medicines, Social Medical Center East, Vienna, Austria.
Acta Ophthalmol. 2015 Sep;93(6):533-8. doi: 10.1111/aos.12670. Epub 2015 Feb 12.
Previous studies have indicated that the immune system is involved in the pathogenesis of the AMD. Increased visceral fat, in addition, has a pro-inflammatory effect on the organism by producing or influencing different kinds of inflammatory factors. The aim of this study is to determine the relationship of body fat distribution in patients with age-related macula degeneration in comparison to a control group in the Austrian population.
In this case-control study, body weight and height, and body mass index (BMI) were measured for each subject in 54 patients with exudative AMD and compared to 46 gender- and age-matched healthy control subjects. Body composition and abdominal fat areas were measured using dual-energy X-ray absorptiometry (DEXA). Data on age, gender distribution, smoking history and systemic diseases, respectively, were compared. The inflammatory markers CRP, tumour necrosis factor-alpha (TNF-alpha), leptin, amyloid A, amyloid beta and interleukin-6 (IL-6) were assayed by ELISA (R&D).
DEXA revealed central-abdominal-to-total body fat ratio of 0.073 +/- 0.011 in AMD patients compared to 0.061 +/- 0.013 in the controls (p <0.001; d = 0.98). The calculation of BMI has provided a significant result (p =0.045). U-test results for Aß1-42, IL-6, SAA and CRP each were significant (p < 0.05), with higher values in AMD patients. Leptin, TNF-alpha and Aß1-40 showed no significant differences between the groups.
Our results suggest that abdominal fat distribution is significantly associated with age-related macular degeneration. Analysis of patients with exudative AMD revealed higher levels of CRP, amyloid ß1-42, IL-6 and amyloid alpha.
先前的研究表明免疫系统参与了年龄相关性黄斑变性（AMD）的发病机制。此外，内脏脂肪增加会通过产生或影响多种炎症因子对机体产生促炎作用。本研究的目的是确定奥地利人群中年龄相关性黄斑变性患者与对照组相比身体脂肪分布的关系。
在这项病例对照研究中，测量了54例渗出性AMD患者的体重、身高和体重指数（BMI），并与46例年龄和性别匹配的健康对照者进行比较。使用双能X线吸收法（DEXA）测量身体成分和腹部脂肪面积。分别比较了年龄、性别分布、吸烟史和全身疾病的数据。通过酶联免疫吸附测定（ELISA，R&D）检测炎症标志物C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、瘦素、淀粉样蛋白A、淀粉样蛋白β和白细胞介素-6（IL-6）。
DEXA显示AMD患者的腹部中心脂肪与全身脂肪之比为0.073±0.011，而对照组为0.061±0.013（p<0.001；效应量d=0.98）。BMI的计算得出了显著结果（p=0.045）。Aβ1-42、IL-6、血清淀粉样蛋白A（SAA）和CRP的U检验结果均具有显著性（p<0.05），AMD患者的值更高。瘦素、TNF-α和Aβ1-40在两组之间没有显著差异。
我们的结果表明腹部脂肪分布与年龄相关性黄斑变性显著相关。对渗出性AMD患者的分析显示CRP、淀粉样蛋白β1-42、IL-6和淀粉样蛋白α水平较高。
