Elmallah Randa K, Cherian Jeffrey J, Jauregui Julio J, Bhowmik-Stoker Manoshi, Beaver Walter B, Mont Michael A
Rubin Institute for Advanced Orthopedics, Center for Joint Preservation and Replacement, Sinai Hospital of Baltimore, Baltimore, Maryland.
Stryker Orthopaedic, Mahwah, New Jersey.
J Arthroplasty. 2015 Jul;30(7):1150-3. doi: 10.1016/j.arth.2015.01.050. Epub 2015 Feb 7.
The SF-6D, a health-related quality-of-life measure, assigns value to patients' perception of their health. We determined SF-6D values of 844 TKA patients, deduced clinical relevance of value changes using effect size, and compared these to clinical and functional improvements 6weeks, 3months, and 1 through 5years post-operatively. The SF-6D significantly improved at all follow-ups after 6weeks. The effect size indicated clinical relevance at every follow-up. The KSS improved at all follow-ups (+43, +51, +56, +57, +57 points), and LEAS scores improved at follow-ups after 6weeks (+1 point at 3months, +2 points thereafter), correlating with SF-6D changes. Deducing utility scores facilitates cost analyses, allowing clinicians to deduce quality-adjusted life-years and economic impacts of treatments.
SF-6D是一种与健康相关的生活质量衡量指标，用于评估患者对自身健康的认知。我们确定了844例全膝关节置换术（TKA）患者的SF-6D值，使用效应量推导值变化的临床相关性，并将其与术后6周、3个月以及1至5年的临床和功能改善情况进行比较。术后6周后的所有随访中，SF-6D均有显著改善。效应量表明每次随访均具有临床相关性。膝关节协会评分（KSS）在所有随访中均有所改善（分别提高43、51、56、57、57分），腿部症状和功能评估量表（LEAS）得分在术后6周后的随访中有所改善（3个月时提高1分，此后提高2分），与SF-6D的变化相关。推导效用分数有助于进行成本分析，使临床医生能够推断治疗的质量调整生命年和经济影响。
