Elmallah Randa K, Chughtai Morad, Khlopas Anton, Bhowmik-Stoker Manoshi, Bozic Kevin J, Kurtz Steven M, Mont Michael A
Department of Orthopaedic Surgery, University of Mississippi, Jackson, Mississippi.
Department of Orthopaedic Surgery, Cleveland Clinic, Cleveland, Ohio.
J Arthroplasty. 2017 Feb;32(2):351-354. doi: 10.1016/j.arth.2016.08.006. Epub 2016 Aug 20.
With the implementation of the Patient Protection and Affordable Care Act, cost-effectiveness analyses are becoming increasingly important for resource allocation, and particularly for the justification of costly procedures, such as total knee and total hip arthroplasties (TKAs and THAs). Therefore, using the Short Form-6D (SF-6D) utility values, the purpose of this study was to determine (1) the quality-adjusted life years (QALYs) gained and (2) and the cost-effectiveness of undergoing THA and TKA.
A total of 844 patients (357 men, 487 women) who had a mean age of 65 years (range, 39 to 80 years) underwent primary TKA, and 224 patients who had a mean age of 69 years (range, 44 to 88 years) underwent primary THAs at 7 institutions. The SF-6D values were derived for each patient preoperatively and at 1-year follow-up. QALYs were estimated at 1 year, and lifetime QALYs gained were determined using predicted life-expectancy values, at a discounted rate of 3% per year of life expectancy, to reflect a diminishing gain with time. National-level costs were determined using the 2011 Nationwide Inpatient Sample, and incremental cost-effectiveness ratios (ICER) were deduced for both groups.
The preoperative SF-6D values for the THA and TKA cohorts were 0.614 (range, 0.37 to 1) and 0.62 (range, 0.3 to 0.93). Postoperatively, SF-6D values improved significantly at 1 year in both groups. One-year QALYs for TKA and THA were 0.768 and 0.799. Lifetime QALYs gained for the groups were 2.07 and 1.85 (1.39 and 1.34 if discounted at a rate of 3% per year). The estimated ICER for TKA vs baseline presurgery was $43,107 per QALY, and $39,453 per QALY for THA vs baseline presurgery.
The ICER showed that THA and TKA are cost-effective, compared to the $50,000 USD/QALY threshold for cost-effectiveness, and justify resources allocated to these surgeries. The SF-6D can utilize existing functional outcome data, which makes these cost calculations considerably easier and more feasible for practicing orthopedists.
随着《患者保护与平价医疗法案》的实施,成本效益分析对于资源分配愈发重要,尤其对于诸如全膝关节置换术和全髋关节置换术(TKA和THA)这类昂贵手术的合理性论证而言。因此,本研究旨在利用简式健康调查6维度(SF - 6D)效用值,确定(1)获得的质量调整生命年(QALY)以及(2)接受THA和TKA的成本效益。
共有844例患者(357例男性,487例女性)接受了初次TKA,平均年龄65岁(范围39至80岁),224例患者接受了初次THA,平均年龄69岁(范围44至88岁),这些患者来自7家机构。术前及术后1年随访时获取每位患者的SF - 6D值。对1年时的QALY进行估算,并使用预期寿命值确定终身获得的QALY,预期寿命的年贴现率为3%,以反映随着时间推移收益递减。利用2011年全国住院患者样本确定国家级成本,并推导两组的增量成本效益比(ICER)。
THA和TKA队列术前的SF - 6D值分别为0.614(范围0.37至1)和0.62(范围0.3至0.93)。术后,两组患者1年时的SF - 6D值均显著改善。TKA和THA的1年QALY分别为0.768和0.799。两组终身获得的QALY分别为2.07和1.85(若按每年3%贴现则分别为1.39和1.34)。TKA与术前基线相比的估计ICER为每QALY 43,107美元,THA与术前基线相比为每QALY 39,453美元。
与每QALY 50,000美元的成本效益阈值相比,ICER表明THA和TKA具有成本效益,证明了分配给这些手术的资源是合理的。SF - 6D能够利用现有的功能结局数据,这使得这些成本计算对于骨科医生来说更加容易且可行。