Stoeckel M Cornelia, Esser Roland W, Gamer Matthias, Kalisch Raffael, Büchel Christian, von Leupoldt Andreas
Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Neuroimaging Center Mainz (NIC), Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University Medical Center, Mainz, Germany.
Psychophysiology. 2015 Jul;52(7):973-6. doi: 10.1111/psyp.12417. Epub 2015 Feb 16.
Dyspnea anticipation and perception varies largely between individuals. To investigate whether genetic factors related to negative affect such as the 5-HTTLPR polymorphism impact this variability, we investigated healthy, 5-HTTLPR stratified volunteers using resistive load induced dyspnea together with fMRI. Alternating blocks of severe and mild dyspnea ("perception") were differentially cued ("anticipation") and followed by intensity and unpleasantness ratings. In addition, volunteers indicated their anticipatory fear during the anticipation periods. There were no genotype-based group differences concerning dyspnea intensity and unpleasantness or brain activation during perception of severe vs. mild dyspnea. However, in risk allele carriers, higher anticipatory fear was paralleled by stronger amygdala activation during anticipation of severe vs. mild dyspnea. These results suggest a role of the 5-HTTLPR genotype in fearful dyspnea anticipation.
呼吸困难的预期和感知在个体之间差异很大。为了研究与消极情绪相关的遗传因素（如5-羟色胺转运体基因相关多态性（5-HTTLPR））是否会影响这种变异性，我们使用阻力负荷诱发的呼吸困难并结合功能磁共振成像（fMRI）对健康的、按5-HTTLPR分层的志愿者进行了研究。交替出现的重度和轻度呼吸困难（“感知”）被给予不同的提示（“预期”），随后进行强度和不愉快程度评分。此外，志愿者在预期期间表明了他们的预期恐惧。在重度与轻度呼吸困难的感知过程中，关于呼吸困难强度、不愉快程度或大脑激活情况，不存在基于基因型的组间差异。然而，在风险等位基因携带者中，在预期重度与轻度呼吸困难时，较高的预期恐惧与更强的杏仁核激活同时出现。这些结果表明5-HTTLPR基因型在恐惧性呼吸困难预期中发挥作用。
