路易斯酸促进吡啶的亲核芳香取代和共轭加成反应。
Lewis acid activation of pyridines for nucleophilic aromatic substitution and conjugate addition.
机构信息
Centre for Doctoral training at the Centre for Sustainable Chemical Technologies, Department of Chemistry, University of Bath, Bath, BA2 7AY (UK).
出版信息
ChemSusChem. 2015 Mar;8(6):1083-7. doi: 10.1002/cssc.201403154. Epub 2015 Feb 13.
PMID:25684444
Abstract
A clean, mild and sustainable method for the functionalization of pyridines and their analogues is reported. A zinc-based Lewis acid is used to activate pyridine and its analogues towards nucleophilic aromatic substitution, conjugate addition, and cyclization reactions by binding to the nitrogen on the pyridine ring and activating the pyridine ring core towards further functionalization.
摘要
本文报道了一种清洁、温和且可持续的吡啶及其类似物功能化方法。通过与吡啶环上的氮原子结合并使吡啶环核心进一步功能化，锌基路易斯酸可用于激活吡啶及其类似物，从而促进亲核芳香取代、共轭加成和环化反应。
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