Raja V P Alex, Tenti Giammarco, Perumal Subbu, Menéndez J Carlos
Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Chem Commun (Camb). 2014 Oct 21;50(82):12270-2. doi: 10.1039/c4cc01791a.
The InCl3-catalyzed sequential multicomponent reaction between 2-furfurylamine, β-dicarbonyl compounds and α,β-unsaturated aldehydes in ethanol, followed by microwave irradiation in solvent-free conditions, afforded good to excellent yields of highly substituted pyridines, with loss of a 2-furylmethyl side chain. The method was also adapted to the synthesis of quinolones, isoquinolines, phenanthridines and more complex fused pyridine systems.
在乙醇中，三氯化铟催化2-糠胺、β-二羰基化合物与α,β-不饱和醛之间的连续多组分反应，随后在无溶剂条件下进行微波辐射，得到了产率良好至优异的高度取代吡啶，同时失去了一个2-呋喃甲基侧链。该方法还适用于喹诺酮、异喹啉、菲啶及更复杂的稠合吡啶体系的合成。
