Vardar-Yagli Naciye, Sener Gul, Saglam Melda, Calik-Kutukcu Ebru, Arikan Hulya, Inal-Ince Deniz, Savci Sema, Altundag Kadri, Kutluk Tezer, Ozisik Yavuz, Kaya Ergun Baris
Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Hacettepe University, Ankara, Turkey E-mail :
Asian Pac J Cancer Prev. 2015;16(2):585-9. doi: 10.7314/apjcp.2015.16.2.585.
Physical inactivity may an important outcome in the prognosis of breast cancer. Physical activity levels decrease significantly for breast cancer patients following the treatment and remain low after oncology treatment is completed. The aim of this study was to determine physical activity levels and to examine associations among physical activity, comorbidity, functional capacity, peripheral muscle strength, and psychosocial status in breast cancer patients. Forty breast cancer survivors were included in this study. Demographic and clinical characteristics were recorded. Physical activity was assessed with a short form of the International Physical Activity Questionnaire (IPAQ). We defined comorbid diseases according to the Charlson Comorbidity Index (CCI). Functional capacity was evaluated with a six-minute walk test (6MWT). Peripheral muscle strength was measured for quadriceps femoris muscle with a hand-held dynamometer. Psychosocial status was measured with the Hospital Anxiety Depression Scale (HADS). Forty percent of patients were inactive. The IPAQ total score was significantly related with quadriceps muscle strength (r=0.492; p<0.001) and HADS depression score (r=0.341; p<0.05). Marked correlations were also observed between IPAQ walking score and quadriceps muscle strength (r=0.449; p<0.001), HADS depression score (r=0.341; p<0.05), and CCI (r=-0.433; p<0.001). The CCI score was also markedly associated with quadriceps muscle strength (r=-0.413; p<0.001). 6MWT distance was not significantly correlated with any of the parameters. Regression analyses revealed that psychosocial status and peripheral muscle strength were significant predictors of physical activity estimated with the IPAQ short form and when combined, they explained 35% of the variance. Comorbidities, peripheral muscle strength and psychosocial status partially explain the variability of physical activity level in breast cancer survivors. These results suggest that physical inactivity contributes to worsening health in breast cancer survivors.
身体活动不足可能是乳腺癌预后的一个重要结果。乳腺癌患者在治疗后身体活动水平显著下降，并且在肿瘤治疗完成后仍维持在较低水平。本研究的目的是确定乳腺癌患者的身体活动水平，并探讨身体活动、合并症、功能能力、外周肌肉力量和心理社会状态之间的关联。本研究纳入了40名乳腺癌幸存者。记录了人口统计学和临床特征。使用国际身体活动问卷简表（IPAQ）评估身体活动情况。我们根据Charlson合并症指数（CCI）定义合并症。通过六分钟步行试验（6MWT）评估功能能力。使用手持测力计测量股四头肌的外周肌肉力量。使用医院焦虑抑郁量表（HADS）测量心理社会状态。40%的患者身体活动不足。IPAQ总分与股四头肌力量显著相关（r = 0.492；p < 0.001）以及HADS抑郁评分显著相关（r = 0.341；p < 0.05）。在IPAQ步行评分与股四头肌力量（r = 0.449；p < 0.001）、HADS抑郁评分（r = 0.341；p < 0.05）和CCI（r = -0.433；p < 0.001）之间也观察到显著相关性。CCI评分也与股四头肌力量显著相关（r = -0.413；p < 0.001）。6MWT距离与任何参数均无显著相关性。回归分析显示，心理社会状态和外周肌肉力量是用IPAQ简表估计的身体活动的显著预测因素，并且两者结合时，它们解释了35%的方差。合并症、外周肌肉力量和心理社会状态部分解释了乳腺癌幸存者身体活动水平的变异性。这些结果表明，身体活动不足会导致乳腺癌幸存者健康状况恶化。
