Physical education institute, Henan University of Economics and Law, Zhengzhou, China.
College of Continuing Education, Henan Quality Polytechnic, Pingdingshan, China.
Cell Commun Signal. 2024 May 7;22(1):260. doi: 10.1186/s12964-024-01634-6.
The emergence of drug resistance is a substantial obstacle to the effective management of breast cancer, which is the primary cause of cancer-related deaths in women worldwide. To facilitate the development of targeted therapies that can effectively overcome drug resistance, it is crucial to possess a comprehensive comprehension of the molecular mechanisms that underpin resistance to breast cancer treatment. So far, considerable progress has been made in the field of exercise-oncology research and overcome drug resistance, specifically about breast cancer. Evidence has suggested that participation in physical activity is correlated with a decrease in reappearance and fatality rates of breast cancer patients. It has been reported that participation in physical activity can yield favorable outcomes in the prevention, treatment, and post-treatment of breast cancer. An increasing body of empirical evidence suggests that participation in physical activity can alter diverse biological mechanisms, potentially augmenting breast cancer treatments' efficacy. Comparing increased physical activity versus reduced physical activity in breast cancer patients who received chemotherapy, radiotherapy, and surgery supported the significance of exercise in comprehensive care strategies to enhance overall health and treatment efficacy. Furthermore, previous studies have reported that physical activity can enhance the efficacy of breast cancer treatments. This review provides the current literature regarding the influence of physical activity on the occurrence and progression of breast cancer.
耐药性的出现是有效管理乳腺癌的一个重大障碍，这也是全球女性癌症相关死亡的主要原因。为了开发能够有效克服耐药性的靶向治疗方法，全面了解乳腺癌治疗耐药性的分子机制至关重要。迄今为止，运动肿瘤学研究领域在克服耐药性方面，特别是在乳腺癌方面已经取得了相当大的进展。有证据表明，参加体育活动与降低乳腺癌患者的复发率和死亡率有关。据报道，参加体育活动可以在乳腺癌的预防、治疗和治疗后产生有利的结果。越来越多的经验证据表明，参加体育活动可以改变多种生物学机制，可能增强乳腺癌治疗的疗效。比较接受化疗、放疗和手术的乳腺癌患者增加或减少体力活动，支持运动在增强整体健康和治疗效果的综合护理策略中的重要性。此外，先前的研究报告称，体育活动可以增强乳腺癌治疗的疗效。本综述提供了关于体力活动对乳腺癌发生和发展影响的当前文献。
