Omar O A, Hoskin P J, Johnston A, Hanks G W, Turner P
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, UK.
J Pharm Pharmacol. 1989 Apr;41(4):275-7. doi: 10.1111/j.2042-7158.1989.tb06452.x.
The influence of temperature and concentration on diamorphine stability during storage over 8 weeks has been investigated. Ampoules containing diamorphine hydrochloride in concentrations from 0.98-250 mg mL-1 have been stored at -20, 4, 21 and 37 degrees C for 8 weeks. Their content of diamorphine, 6-monoacetylmorphine and morphine, on measurement by high performance liquid chromatography after 1, 2, 4, 6 and 8 weeks storage changed to slow degradation of diamorphine at all concentrations at temperatures of 4 degrees C and above. This was accompanied by a corresponding increase in 6-monoacetylmorphine and morphine. There was an associated fall in pH and development of a strong odour characteristic of acetic acid. Precipitation and a white turbidity seen in solutions of 15.6 mg mL-1 and above, appeared after 2 weeks incubation.
