Yamamoto M, Shimizu M
Department of Pharmacology, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan.
J Pharm Pharmacol. 1989 Apr;41(4):284-6. doi: 10.1111/j.2042-7158.1989.tb06456.x.
The effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride] on cognitive disturbance in mice subjected to cycloheximide have been examined. Indeloxazine ameliorated cycloheximide-induced amnesia in mice, indicating a facilitatory effect of this drug on cerebral functions. Piracetam, Cahopantenate, dihydroergotoxine and viloxazine did not show significant effect on the amnesia. These results suggest that indeloxazine possesses a wider pharmacological profile than piracetam, Cahopantenate, dihydroergotoxine and viloxazine in anti-amnesic activities.
已研究了盐酸茚达品[（±）-2-（茚-7-基氧基甲基）吗啉盐酸盐]对环己酰亚胺所致小鼠认知障碍的影响。茚达品改善了环己酰亚胺诱导的小鼠失忆，表明该药物对脑功能有促进作用。吡拉西坦、卡霍泮酯、双氢麦角毒碱和维洛沙嗪对失忆无显著影响。这些结果表明，在抗失忆活性方面，茚达品比吡拉西坦、卡霍泮酯、双氢麦角毒碱和维洛沙嗪具有更广泛的药理作用谱。
