盐酸茚达品对衰老加速小鼠被动回避行为的影响。

Effects of indeloxazine hydrochloride on passive avoidance behavior of senescence-accelerated mice.

作者信息

Yamamoto M, Iwai A, Kawabata S, Ozawa Y, Shimizu M

机构信息

Department of Pharmacology, Central Research Laboratories, Yamanouchi Pharmaceutical Co. Ltd., Tokyo, Japan.

出版信息

Eur J Pharmacol. 1989 Jul 18;166(2):345-8. doi: 10.1016/0014-2999(89)90081-2.

DOI:10.1016/0014-2999(89)90081-2

PMID:2792199

Abstract

The effects of indeloxazine hydrochloride on disturbances of passive avoidance behavior in senescence-accelerated mice (SAM) were observed. The step-through latency of SAM-P/8/Ta (SAM-P/8, senescence-prone substrain) was significantly shorter than that of SAM-R/1/Ta (SAM-R/1, senescence-resistant substrain). The administration of indeloxazine (10-30 mg/kg p.o.) or dihydroergotoxine (1 mg/kg i.p.) for 3 weeks significantly prolonged the step-through latency of SAM-P/8/Ta whereas piracetam (30-300 mg/kg p.o.) did not. These results suggest that indeloxazine has a facilitatory effect on cerebral functions and that it has a broader pharmacological profile in anti-amnesic activities than piracetam.

摘要

观察了盐酸茚达品对加速衰老小鼠（SAM）被动回避行为障碍的影响。SAM-P/8/Ta（SAM-P/8，易衰老亚系）的穿通潜伏期明显短于SAM-R/1/Ta（SAM-R/1，抗衰老亚系）。给予茚达品（10 - 30毫克/千克，口服）或双氢麦角毒碱（1毫克/千克，腹腔注射）3周可显著延长SAM-P/8/Ta的穿通潜伏期，而吡拉西坦（30 - 300毫克/千克，口服）则无此作用。这些结果表明，茚达品对脑功能有促进作用，且在抗遗忘活性方面比吡拉西坦具有更广泛的药理学特性。