多读者纵向试验中腕关节OMERACT磁共振成像关节间隙狭窄评分的验证
Validation of the OMERACT Magnetic Resonance Imaging Joint Space Narrowing Score for the Wrist in a Multireader Longitudinal Trial.
作者信息
Glinatsi Daniel, Lillegraven Siri, Haavardsholm Espen A, Eshed Iris, Conaghan Philip G, Peterfy Charles, Gandjbakhch Frédérique, Bird Paul, Bøyesen Pernille, Døhn Uffe M, Genant Harry K, Østergaard Mikkel
机构信息
From the Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, University of Copenhagen and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, Diakonhjemmet Hospital, University of Oslo, Oslo, Norway; Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, UK; Spire Sciences Inc., Boca Raton, Florida, USA; Department of Rheumatology, Pitié Salpêtrière Hospital, APHP, Université Paris 6-UPMC, Paris, France; University of New South Wales, Sydney, Australia; Medicine and Orthopedics, University of California, San Francisco, and Synarc Inc., San Francisco, California, USA.D. Glinatsi, MD, Research Fellow, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Glostrup Hospital, University of Copenhagen; S. Lillegraven, MD, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital, University of Oslo; E.A. Haavardsholm, MD, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; I. Eshed, MD, Professor of Radiology, Sheba Medical Center; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; C. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; F. Gandjbakhch, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtrière Hospital, APHP, Université Paris 6-UPMC; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Senior Lecturer, University of New South Wales; P. Bøyesen, MD, PhD, Department of Rheumatology, Diakonhjemmet Hospital; U.M. Døhn, MD, PhD, Copenhagen Center for Arthritis Research, Center for Rhe
出版信息
J Rheumatol. 2015 Dec;42(12):2480-5. doi: 10.3899/jrheum.141009. Epub 2015 Feb 15.
OBJECTIVE
To assess the intrareader and interreader agreement and sensitivity to change of the Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing (RAMRIS-JSN) score in the rheumatoid arthritis (RA) wrist in a longitudinal multireader exercise.
METHODS
Coronal T1-weighted MR image sets of 1 wrist from 20 patients with early RA were assessed twice for JSN at 17 sites at baseline and after 36 or 60 months by 4 readers blinded to patient data but not time order. The joints were scored 0-4 according to the OMERACT RAMRIS-JSN score. Intraclass correlation coefficients (ICC), smallest detectable change (SDC), percentage exact/close agreement (PEA/PCA), and standardized response mean (SRM) were calculated.
RESULTS
Median baseline and change score was 10.3 and 1.9, respectively. Intrareader ICC for baseline and change scores was good (≥ 0.50) to very good (≥ 0.80) for all and 3 of 4 readers, respectively. Interreader ICC was very good for change (0.93), while poor for baseline score if all 4 readers were included (0.36), but very good if 1 reader was excluded (0.87). Intrareader and interreader SDC was low (2.34-3.18), except for the intrareader SDC for 1 reader (6.75). The mean PEA/PCA was high for baseline and change scores both within and between the readers (51.5-99.2), except for interreader baseline PEA (14.4). SRM was moderate for all readers (0.55-0.77).
CONCLUSION
The OMERACT RAMRIS-JSN score showed high overall intrareader and interreader reliability, and moderate sensitivity to change, supporting inclusion of the measure as part of the OMERACT RAMRIS system.
目的
在一项纵向多阅片者研究中，评估类风湿关节炎（RA）腕关节的阅片者内和阅片者间一致性，以及风湿病结局评估（OMERACT）类风湿关节炎磁共振成像关节间隙狭窄（RAMRIS-JSN）评分对变化的敏感性。
方法
对20例早期RA患者的1个腕关节的冠状面T1加权磁共振图像集，由4名对患者数据不知情但知晓时间顺序的阅片者，在基线时和36或60个月后对17个部位的关节间隙狭窄（JSN）进行两次评估。根据OMERACT RAMRIS-JSN评分，关节评分为0-4分。计算组内相关系数（ICC）、最小可检测变化（SDC）、精确/相近一致性百分比（PEA/PCA）和标准化反应均值（SRM）。
结果
基线和变化评分的中位数分别为10.3和1.9。所有阅片者以及4名阅片者中的3名阅片者，基线和变化评分的阅片者内ICC分别为良好（≥0.50）至非常好（≥0.80）。阅片者间ICC对变化情况为非常好（0.93），但如果纳入所有4名阅片者，基线评分的ICC较差（0.36），但排除1名阅片者后为非常好（0.87）。阅片者内和阅片者间的SDC较低（2.34-3.18），但1名阅片者的阅片者内SDC除外（6.75）。阅片者内和阅片者间基线及变化评分的平均PEA/PCA较高（51.5-99.2），但阅片者间基线PEA除外（14.4）。所有阅片者的SRM为中等（0.55-0.77）。
结论
OMERACT RAMRIS-JSN评分显示出较高的总体阅片者内和阅片者间可靠性，以及中等的变化敏感性，支持将该测量方法纳入OMERACT RAMRIS系统。
Zotero 插件