OMERACT手部骨关节炎磁共振成像评分系统（HOAMRIS）的纵向可靠性和反应性
The Longitudinal Reliability and Responsiveness of the OMERACT Hand Osteoarthritis Magnetic Resonance Imaging Scoring System (HOAMRIS).
作者信息
Haugen Ida K, Eshed Iris, Gandjbakhch Frederique, Foltz Violaine, Østergaard Mikkel, Bøyesen Pernille, Bird Paul, Genant Harry K, Peterfy Charles G, Conaghan Philip G
机构信息
From the Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; Department of Diagnostic Imaging, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel; Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie, Paris, France; Copenhagen Center for Arthritis Research, Center for Rheumatology and Spinal Diseases, Glostrup Hospital, Glostrup, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Rheumatology, St. George Hospital, Sydney, Australia; St. George Clinical School, University of New South Wales, Sydney, Australia; Departments of Radiology and Medicine, University of California San Francisco, San Francisco, California, USA; Synarc Inc., Newark, California, USA; Spire Sciences Inc., Boca Raton, Florida, USA; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK.I.K. Haugen, MD, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; I. Eshed, MD, Professor of Radiology, Sheba Medical Center, Tel Aviv University; F. Gandjbakhch, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; V. Foltz, MD, Practicing Rheumatologist, Department of Rheumatology, Pitié Salpêtriere Hospital, APHP, Université Pierre et Marie Curie; M. Østergaard, MD, PhD, DMSc, Professor of Rheumatology, Copenhagen Center for Arthritis Research, Center for Rheumatology and Spinal Diseases, Glostrup Hospital, and Department of Clinical Medicine, University of Copenhagen; P. Bøyesen, MD, PhD, Postdoctoral Researcher, Department of Rheumatology, Diakonhjemmet Hospital; P. Bird, BMed (Hons), FRACP, PhD, Practicing Rheumatologist, Department of Rheumatology, St. George Hospital and Senior Lecturer, University of New South Wales; H.K. Genant, MD, FACR, FRC
出版信息
J Rheumatol. 2015 Dec;42(12):2486-91. doi: 10.3899/jrheum.140983. Epub 2015 Sep 1.
OBJECTIVE
To evaluate the interreader reliability of change scores and the responsiveness of the OMERACT Hand Osteoarthritis (OA) Magnetic Resonance Image (MRI) Scoring System (HOAMRIS).
METHODS
Paired MRI (baseline and 5-yr followup) from 20 patients with hand OA were scored with known time sequence by 3 readers according to the HOAMRIS: Synovitis, erosive damage, cysts, osteophytes, cartilage space loss, malalignment, and bone marrow lesions (BML; 0-3 scales with 0.5 increments for synovitis, erosive damage, and BML). Interreader reliability for status and change scores were assessed by intraclass correlation coefficients (ICC), percentage exact agreement and percentage close agreement (PEA/PCA), and smallest detectable change (SDC). Responsiveness was assessed by standardized response means (SRM).
RESULTS
Cross-sectional interreader ICC were good to very good (≥ 0.74) for all features except synovitis, cysts, and malalignment (ICC 0.50-0.58). The range of change values was small, leading to low ICC for change scores. The SDC values for sum scores (total range 0-24) varied between 1.97-3.05 (except 1.08 for malalignment). For status scores, PEA/PCA on scores in individual joints across the readers were 8.1-50.0 and 43.8-78.1, respectively. Similarly, PEA/PCA for change scores were 20.6-63.8 and 66.3-93.1, respectively. All features except cysts and BML demonstrated good responsiveness with higher SRM for sum scores (range 0.46-1.62) than for scores in individual joints (range 0.24-0.73).
CONCLUSION
Good to very good interreader ICC values were found for cross-sectional readings, whereas the longitudinal reliability was lower because of a smaller range of change scores. All features, except cysts and BML, showed good responsiveness.
目的
评估OMERACT手部骨关节炎（OA）磁共振成像（MRI）评分系统（HOAMRIS）中变化分数的阅片者间可靠性及反应度。
方法
对20例手部OA患者的配对MRI（基线和5年随访），由3位阅片者按照HOAMRIS进行评分，已知时间顺序：滑膜炎、侵蚀性损伤、囊肿、骨赘、软骨间隙丢失、排列不齐和骨髓病变（BML；滑膜炎、侵蚀性损伤和BML为0 - 3级，以0.5递增）。通过组内相关系数（ICC）、百分比完全一致和百分比接近一致（PEA/PCA）以及最小可检测变化（SDC）评估阅片者间状态和变化分数的可靠性。通过标准化反应均值（SRM）评估反应度。
结果
除滑膜炎、囊肿和排列不齐（ICC 0.50 - 0.58）外，所有特征的横断面阅片者间ICC均为良好至极优（≥0.74）。变化值范围较小，导致变化分数的ICC较低。总分（总范围0 - 24）的SDC值在1.97 - 3.05之间（排列不齐为1.08除外）。对于状态分数，阅片者间各关节分数的PEA/PCA分别为8.1 - 50.0和43.8 - 78.1。同样，变化分数的PEA/PCA分别为20.6 - 63.8和66.3 - 93.1。除囊肿和BML外，所有特征均显示出良好的反应度，总分的SRM（范围0.46 - 1.62）高于各关节分数的SRM（范围0.24 - 0.73）。
结论
横断面阅片发现阅片者间ICC值良好至极优，而纵向可靠性较低，因为变化分数范围较小。除囊肿和BML外，所有特征均显示出良好的反应度。
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