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苏沃雷生

Suvorexant.

作者信息

Cada Dennis J, Levien Terri L, Baker Danial E

机构信息

Founder and Contributing Editor, The Formulary , Washington State University , Spokane, Washington.

Clinical Professor, College of Pharmacy, Washington State University , Spokane, Washington.

出版信息

Hosp Pharm. 2015 Jan;50(1):59-71. doi: 10.1310/hpj5001-59.

DOI:10.1310/hpj5001-59
PMID:25684802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4321430/
Abstract

Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are sent in print and are also available on-line. Monographs can be customized to meet the needs of a facility. A drug class review is now published monthly with The Formulary Monograph Service. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, call The Formulary at 800-322-4349. The January 2015 monograph topics are ledipasvir/sofosbuvir, eliglustat, naloxegol, pembrolizumab, and dulaglutide injection. The Safety MUE is on ledipasvir/sofosbuvir.

摘要

每月,《处方集专论服务》的订阅者会收到5至6篇关于新发布或处于3期临床试验后期的药物的详细专论。这些专论面向药学与治疗学委员会。订阅者每月还会收到关于对议程以及药房/护理在职培训有用的药物的1页摘要专论。每月还会提供一份全面的目标药物利用评估/用药使用评估(DUE/MUE)。订阅后,专论将以印刷形式发送,也可在线获取。专论可根据机构需求进行定制。现在每月会随《处方集专论服务》发布一份药物类别综述。通过《处方集》的合作,《医院药学》在本专栏发表精选综述。如需了解更多关于《处方集专论服务》的信息,请致电《处方集》800 - 322 - 4349。2015年1月专论主题包括来迪派韦/索磷布韦、依格列斯他、纳洛西醇、派姆单抗和度拉鲁肽注射液。安全性MUE针对来迪派韦/索磷布韦。

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本文引用的文献

1
Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial.苏沃雷生治疗失眠 1 年随后突然停药的安全性和疗效:一项 3 期随机、双盲、安慰剂对照试验。
Lancet Neurol. 2014 May;13(5):461-71. doi: 10.1016/S1474-4422(14)70053-5. Epub 2014 Mar 27.
2
Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men.苏沃雷生,一种食欲素受体拮抗剂,对健康男性多导睡眠图睡眠参数的影响。
Sleep. 2013 Feb 1;36(2):259-67. doi: 10.5665/sleep.2386.
3
Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.食欲素受体拮抗剂治疗失眠:苏沃雷生的随机临床试验。
Neurology. 2012 Dec 4;79(23):2265-74. doi: 10.1212/WNL.0b013e31827688ee. Epub 2012 Nov 28.
4
Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist.新型双重食欲素受体拮抗剂苏沃雷生对睡眠的促进作用。
J Neurogenet. 2011 Mar;25(1-2):52-61. doi: 10.3109/01677063.2011.566953. Epub 2011 Apr 8.
5
Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.发现双重食欲素受体拮抗剂 [(7R)-4-(5-氯-1,3-苯并恶唑-2-基)-7-甲基-1,4-二氮杂环庚烷-1-基][5-甲基-2-(2H-1,2,3-三唑-2-基)苯基]甲酮 (MK-4305) 用于治疗失眠。
J Med Chem. 2010 Jul 22;53(14):5320-32. doi: 10.1021/jm100541c.
6
Orexin receptor antagonists: a new concept in CNS disorders?食欲素受体拮抗剂:中枢神经系统疾病的新概念?
ChemMedChem. 2010 Aug 2;5(8):1197-214. doi: 10.1002/cmdc.201000132.
7
Clinical guideline for the evaluation and management of chronic insomnia in adults.成人慢性失眠评估与管理临床指南
J Clin Sleep Med. 2008 Oct 15;4(5):487-504.