Henriksson R, Grankvist K
Department of Oncology, University of Umeå, Sweden.
Med Oncol Tumor Pharmacother. 1989;6(2):175-8. doi: 10.1007/BF02985242.
The anthracycline epirubicin (0.1-1.0 mg l.-1) caused a dose-dependent inhibition of the clonogenic survival of Chinese hamster fibroblasts. Four antiemetics (dixyrazin, metoclopramide, chlorpromazine and droperidol) augmented the inhibition by epirubicin. Furthermore, by using oxygen consumption as an index, epirubicin-induced free oxygen radical formation was not potentiated by the tested antiemetics. The results justify further studies on the antineoplastic and adverse effects pertaining to interaction between anthracyclines and antiemetics. Finally, the results suggest that interference of antiemetics on fibroblast toxicity does not directly involve the generation of free oxygen radicals.
蒽环类药物表柔比星（0.1 - 1.0毫克/升）对中国仓鼠成纤维细胞的克隆形成存活率产生剂量依赖性抑制。四种止吐药（地昔帕明、甲氧氯普胺、氯丙嗪和氟哌利多）增强了表柔比星的抑制作用。此外，以耗氧量为指标，所测试的止吐药并未增强表柔比星诱导的游离氧自由基形成。这些结果为进一步研究蒽环类药物与止吐药相互作用的抗肿瘤及不良反应提供了依据。最后，结果表明止吐药对成纤维细胞毒性的干扰并不直接涉及游离氧自由基的产生。
