Grankvist K, Bergström P, Henriksson R
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
Biosci Rep. 1990 Apr;10(2):173-7. doi: 10.1007/BF01116576.
The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
