Different effects of chlorpromazine on bleomycin- and epirubicin induced cytotoxicity.
作者信息
Grankvist K, Bergström P, Henriksson R
机构信息
Department of Clinical Chemistry, Umeå University Hospital, Sweden.
出版信息
Biosci Rep. 1990 Apr;10(2):173-7. doi: 10.1007/BF01116576.
PMID:1694095
Abstract
The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was tested in vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
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