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大量脑室内出血的内镜治疗早期经验及文献综述

Early experience in endoscopic management of massive intraventricular hemorrhage with literature review.

作者信息

Idris Zamzuri, Raj Jason, Abdullah Jafri Malin

机构信息

Center for Neuroscience Service and Research, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia ; Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

出版信息

Asian J Neurosurg. 2014 Jul-Sep;9(3):124-9. doi: 10.4103/1793-5482.142731.

Abstract

Massive intraventricular hemorrhage (IVH) is nearly always associated with hydrocephalus and is often treated with prolonged external ventricular drainage (EVD); however this procedure can lead to bacterial ventriculitis and meningitis, which can worsen the clinical outcomes. Endoscopic burr hole surgery to remove the hematomas in lateral and third ventricles is an alternative treatment option. We describe the surgical techniques and benefits of endoscopic surgery for acute massive IVH in four patients and discuss the current published literature-related to this condition. Four patients were treated endoscopically for massive IVH. Three patients presented with secondary IVH due to vascular malformation, tumoral bleed and chronic hypertension, while one case presented as massive primary IVH. Endoscopic wash out and removal of hematomas was normally performed together with an endoscopic third ventriculostomy. Recombinant factor VIIa was only administered prior to surgery for IVH secondary to vascular malformation and for cases with postoperative rebleeding which required second endoscopic surgery. Weaning from ventilator and EVD commenced on day 4 postoperatively. All treated patients recovered and did not require further shunt surgery. Good outcomes obtained may be related to early removal of hematomas, creation of new cerebrospinal fluid diversion pathway after thorough wash-out, early weaning from ventilator and EVD. Endoscopic surgery is beneficial in treating poor grade IVH with Graeb score of more than 6.

摘要

大量脑室内出血(IVH)几乎总是与脑积水相关,并且常采用延长的外部脑室引流(EVD)进行治疗;然而,该操作可能导致细菌性脑室炎和脑膜炎,从而使临床结局恶化。内镜下钻孔手术以清除侧脑室和第三脑室内的血肿是一种替代治疗选择。我们描述了4例急性大量IVH患者的内镜手术技术和益处,并讨论了与该病症相关的当前已发表文献。4例大量IVH患者接受了内镜治疗。3例患者因血管畸形、肿瘤出血和慢性高血压出现继发性IVH,而1例表现为大量原发性IVH。内镜下冲洗和清除血肿通常与内镜下第三脑室造瘘术一起进行。重组凝血因子VIIa仅在继发于血管畸形的IVH手术前以及术后再次出血需要二次内镜手术的病例中使用。术后第4天开始脱机和停用EVD。所有接受治疗的患者均康复,无需进一步的分流手术。获得的良好结局可能与早期清除血肿、彻底冲洗后建立新的脑脊液引流途径、早期脱机和停用EVD有关。内镜手术对于Graeb评分大于6的低级别IVH治疗有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c7f4/4323895/ff9e224f0eb6/AJNS-9-124-g001.jpg

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