Idris Zamzuri, Kandasamy Regunath, Reza Faruque, Abdullah Jafri M
Center for Neuroscience Service and Research, School of Medical Sciences, Center for Neuroscience Service and Research, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia ; Department of Neurosciences, School of Medical Sciences, Center for Neuroscience Service and Research, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia.
Department of Neurosciences, School of Medical Sciences, Center for Neuroscience Service and Research, Universiti Sains Malaysia, Kubang Kerian, 16150 Kota Bharu, Kelantan, Malaysia.
Asian J Neurosurg. 2014 Jul-Sep;9(3):144-52. doi: 10.4103/1793-5482.142734.
Magnetoencephalography (MEG) is a method of functional neuroimaging. The concomitant use of MEG and electrocorticography has been found to be useful in elucidating neural oscillation and network, and to localize epileptogenic zone and functional cortex. We describe our early experience using MEG in neurosurgical patients, emphasizing on its impact on patient management as well as the enrichment of our knowledge in neurosciences.
A total of 10 subjects were included; five patients had intraaxial tumors, one with an extraaxial tumor and brain compression, two with arteriovenous malformations, one with cerebral peduncle hemorrhage and one with sensorimotor cortical dysplasia. All patients underwent evoked and spontaneous MEG recordings. MEG data was processed at band-pass filtering frequency of between 0.1 and 300 Hz with a sampling rate of 1 kHz. MEG source localization was performed using either overdetermined equivalent current dipoles or underdetermined inversed solution. Neuromag collection of events software was used to study brain network and epileptogenic zone. The studied data were analyzed for neural oscillation in three patients; brain network and clinical manifestation in five patients; and for the location of epileptogenic zone and eloquent cortex in two patients.
We elucidated neural oscillation in three patients. One demonstrated oscillatory phenomenon on stimulation of the motor-cortex during awake surgery, and two had improvement in neural oscillatory parameters after surgery. Brain networks corresponding to clinico-anatomical relationships were depicted in five patients, and two networks were illustrated here. Finally, we demonstrated epilepsy cases in which MEG data was found to be useful in localizing the epileptogenic zones and functional cortices.
The application of MEG while enhancing our knowledge in neurosciences also has a useful role in epilepsy and awake surgery.
脑磁图（MEG）是一种功能性神经成像方法。已发现同时使用MEG和皮质脑电图有助于阐明神经振荡和神经网络，并定位致痫区和功能皮质。我们描述了我们在神经外科患者中使用MEG的早期经验，重点强调其对患者管理的影响以及对我们神经科学知识的丰富。
共纳入10名受试者；5例患者患有轴内肿瘤，1例患有轴外肿瘤并伴有脑受压，2例患有动静脉畸形，1例患有脑桥出血，1例患有感觉运动皮质发育异常。所有患者均接受了诱发和自发MEG记录。MEG数据在0.1至300 Hz的带通滤波频率下进行处理，采样率为1 kHz。使用超定等效电流偶极子或欠定逆解进行MEG源定位。使用Neuromag事件采集软件研究脑网络和致痫区。对3例患者的神经振荡、5例患者的脑网络和临床表现以及2例患者的致痫区和明确皮质的位置进行了研究数据分析。
我们阐明了3例患者的神经振荡。1例在清醒手术期间刺激运动皮质时表现出振荡现象，2例术后神经振荡参数有所改善。5例患者描绘了与临床解剖关系相对应的脑网络，此处展示了2个网络。最后，我们展示了MEG数据有助于定位致痫区和功能皮质的癫痫病例。
MEG的应用在增强我们神经科学知识的同时，在癫痫和清醒手术中也具有重要作用。
