Miyata T, Yokoyama I, Todo S, Tzakis A, Selby R, Starzl T E
Department of Surgery, University Health Center, Pittsburgh, Pennsylvania.
Lancet. 1989 Jul 22;2(8656):189-91. doi: 10.1016/s0140-6736(89)90373-5.
Plasma endotoxin was measured in 64 patients undergoing primary liver replacement. Endotoxin concentrations increased during the anhepatic phase of the operations, and remained high for several days. Although the severity of endotoxaemia did not correlate with duration of the anhepatic phase, there was a correlation between endotoxaemia and the need for perioperative platelet transfusions, ventilator dependency postoperatively, and one-month case-fatality.
对64例接受原位肝移植的患者进行了血浆内毒素检测。术中无肝期内毒素浓度升高，并持续数天维持在高位。虽然内毒素血症的严重程度与无肝期的持续时间无关，但内毒素血症与围手术期血小板输注的需求、术后呼吸机依赖以及1个月病死率之间存在相关性。
