Assanov Gani S, Zhanabaev Zeinulla Zh, Govorov Alexander O, Neiman Alexander B
Al-Farabi Kazakh National University, al-Farabi Avenue, 71, Almaty 050038, Kazakhstan.
Department of Physics and Astronomy, Ohio University, Athens, Ohio 45701, USA.
Eur Phys J Spec Top. 2013 Oct 1;222(10):2697-2704. doi: 10.1140/epjst/e2013-02049-0.
We study the transient dynamics of biological oscillators subjected to brief heat pulses. A prospective well-defined experimental system for thermal control of oscillators is the peripheral electroreceptors in paddlefish. Epithelial cells in these receptors show spontaneous voltage oscillations which are known to be temperature sensitive. We use a computational model to predict the effect of brief thermal pulses in this system. In our model thermal stimulation is realized through the light excitation of gold nanoparticles delivered in close proximity to epithelial cells and generating heat due to plasmon resonance. We use an ensemble of modified Morris-Lecar systems to model oscillatory epithelial cells. First, we validate that the model quantitatively reproduces the dynamics of epithelial oscillations in paddlefish electroreceptors, including responses to static and slow temperature changes. Second, we use the model to predict transient responses to short heat pulses generated by the light actuated gold nanoparticles. The model predicts that the epithelial oscillators can be partially synchronized by brief 5 - 15 ms light stimuli resulting in a large-amplitude oscillations of the mean field potential.
我们研究了遭受短暂热脉冲的生物振荡器的瞬态动力学。用于振荡器热控制的一个前景明确的实验系统是匙吻鲟的外周电感受器。这些感受器中的上皮细胞表现出自发的电压振荡，已知其对温度敏感。我们使用一个计算模型来预测该系统中短暂热脉冲的影响。在我们的模型中，热刺激通过对靠近上皮细胞递送的金纳米颗粒进行光激发来实现，金纳米颗粒由于等离子体共振而产生热量。我们使用一组经过修改的Morris-Lecar系统来模拟振荡的上皮细胞。首先，我们验证该模型定量地再现了匙吻鲟电感受器中上皮振荡的动力学，包括对静态和缓慢温度变化的响应。其次，我们使用该模型来预测对光驱动的金纳米颗粒产生的短热脉冲的瞬态响应。该模型预测，上皮振荡器可以通过5 - 15毫秒的短暂光刺激实现部分同步，从而导致平均场电位的大幅振荡。
