镰状细胞病能否预防糖尿病？横断面研究。
Does Sickle Cell Disease Protect Against Diabetes Mellitus?: Cross-sectional study.
作者信息
Suwaidan Ali A, Al-Qurashi Fathia, Whitford David L
机构信息
School of Medicine, Royal College of Surgeons in Ireland Medical University of Bahrain, Busaiteen, Bahrain.
Department of Haematology, Royal Albert Edward Infirmary, Wrightington, Wigan & Leigh NHS Foundation Trust, UK.
出版信息
Sultan Qaboos Univ Med J. 2015 Feb;15(1):e116-e119. Epub 2015 Jan 21.
OBJECTIVES
The co-existence of diabetes mellitus (DM) and sickle cell disease (SCD) is rare. This study aimed to explore whether SCD patients have the same DM prevalence as the general population in a country with a high prevalence of DM.
METHODS
This cross-sectional study included all SCD adult patients admitted to Salmaniya Medical Complex, Bahrain, between 2003 and 2010 (n = 2,204). A random sample (n = 520) was taken to establish the prevalence of DM. Laboratory records were examined to determine the presence of DM.
RESULTS
There were 376 SCD patients with complete records; of these, 24 (6.4%) had DM. The age- and sex-standardised prevalence of DM was 8.3%.
CONCLUSION
While the prevalence of DM in SCD patients in Bahrain was high, it was lower than expected in this population. SCD may have a protective effect towards DM development. However, the impact of these two conditions on vascular diseases suggest a need for screening and aggressive treatment in this population.
目的
糖尿病（DM）与镰状细胞病（SCD）并存的情况较为罕见。本研究旨在探讨在一个糖尿病患病率较高的国家，SCD患者的糖尿病患病率是否与普通人群相同。
方法
这项横断面研究纳入了2003年至2010年间入住巴林萨勒曼尼亚医疗中心的所有成年SCD患者（n = 2204）。抽取了一个随机样本（n = 520）以确定糖尿病的患病率。检查实验室记录以确定是否存在糖尿病。
结果
有376例SCD患者有完整记录；其中24例（6.4%）患有糖尿病。糖尿病的年龄和性别标准化患病率为8.3%。
结论
虽然巴林SCD患者的糖尿病患病率较高，但低于该人群的预期。SCD可能对糖尿病的发展具有保护作用。然而，这两种疾病对血管疾病的影响表明，该人群需要进行筛查和积极治疗。
Zotero 插件