Ibrahim Nuraddeen, Lugga Abubakar Sani, Ibrahim Olayinka Rasheed
Department of Paediatrics, Federal Medical Centre, Katsina State, Nigeria.
Pan Afr Med J. 2019 May 7;33:7. doi: 10.11604/pamj.2019.33.7.18971. eCollection 2019.
Sickle cell anaemia (SCA) and type 1 diabetes mellitus (type 1 DM) are chronic medical conditions whose co-existence is uncommon in childhood. Furthermore, complications of SCA such as mesenteric crisis typically present with abdominal pain, which is also common in children with diabetic ketoacidosis (DKA) and this may possess diagnostic challenge. Herewith in, we report a rare case of a nine-year-old child with homozygous sickle cell anaemia, who presented with features of mesenteric crisis and diabetic ketoacidosis. The DKA was diagnosed based on the presence of hyperglycaemia (32.2 mmol/L), ketonaemia (4.6 mmol/L) and acidosis (11.6 mmol/L). The fluids deficit was corrected over 24 hours, with improvement in the vaso-occlusive crises (VOC) without precipitating cerebral oedema.
镰状细胞贫血(SCA)和1型糖尿病(1型DM)是慢性疾病,它们在儿童期并存的情况并不常见。此外,SCA的并发症如肠系膜危象通常表现为腹痛,这在糖尿病酮症酸中毒(DKA)患儿中也很常见,这可能带来诊断挑战。在此,我们报告一例罕见的9岁纯合子镰状细胞贫血患儿,其表现出肠系膜危象和糖尿病酮症酸中毒的特征。根据高血糖(32.2 mmol/L)、酮血症(4.6 mmol/L)和酸中毒(11.6 mmol/L)诊断为DKA。在24小时内纠正了液体不足,血管闭塞性危象(VOC)有所改善,且未引发脑水肿。