Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27858, USA.
J Adv Res. 2014 Mar;5(2):137-45. doi: 10.1016/j.jare.2013.03.008. Epub 2013 Apr 3.
Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB1R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary knowledge regarding the cannabinoids centrally elicited cardiovascular responses and the possible underlying signaling mechanisms. The current review focuses on the rostral ventrolateral medulla (RVLM) as the primary brainstem nucleus implicated in CB1R-evoked pressor response.
大麻素在实验动物中引起复杂的血液动力学反应，涉及外周和中枢部位。已表明中枢给予的大麻素有引起升压反应的趋势。然而，对于大麻素受体 1（CB1R）引起的升压反应的机制知之甚少。在这篇综述中，我们提供了关于大麻素中枢引起心血管反应的当代知识概述，以及可能的潜在信号转导机制。本综述重点介绍延髓头端腹外侧区（RVLM）作为与 CB1R 引起的升压反应有关的主要脑干核。
