Keloid Pathogenesis: Potential Role of Cellular Fibronectin with the EDA Domain.
作者信息
Andrews Jonathan P, Marttala Jaana, Macarak Edward, Rosenbloom Joel, Uitto Jouni
机构信息
Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; The Joan and Joel Rosenbloom Research Center for Fibrotic Diseases, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
出版信息
J Invest Dermatol. 2015 Jul;135(7):1921-1924. doi: 10.1038/jid.2015.50. Epub 2015 Feb 16.
Abstract
摘要
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本文引用的文献
1
FibronectinEDA promotes chronic cutaneous fibrosis through Toll-like receptor signaling.
Sci Transl Med. 2014 Apr 16;6(232):232ra50. doi: 10.1126/scitranslmed.3008264.
2
The evidence for the role of transforming growth factor-beta in the formation of abnormal scarring.
Int Wound J. 2011 Jun;8(3):218-23. doi: 10.1111/j.1742-481X.2011.00771.x. Epub 2011 Mar 30.
3
Keloids: current concepts of pathogenesis (review).
Int J Mol Med. 2009 Sep;24(3):283-93. doi: 10.3892/ijmm_00000231.
4
New insights into form and function of fibronectin splice variants.
J Pathol. 2008 Sep;216(1):1-14. doi: 10.1002/path.2388.
5
Fibronectin gene expression differs in normal and abnormal human wound healing.
Wound Repair Regen. 1994 Jan;2(1):3-19. doi: 10.1046/j.1524-475X.1994.20104.x.
6
Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan.
J Cell Biol. 2003 Jul 7;162(1):149-60. doi: 10.1083/jcb.200212079.
7
The extra domain A of fibronectin activates Toll-like receptor 4.
J Biol Chem. 2001 Mar 30;276(13):10229-33. doi: 10.1074/jbc.M100099200. Epub 2001 Jan 9.
8
Regulation of fibronectin EDA exon alternative splicing: possible role of RNA secondary structure for enhancer display.
Mol Cell Biol. 1999 Apr;19(4):2657-71. doi: 10.1128/MCB.19.4.2657.
9
Fibronectin (FN) in hypertrophic scars and keloids.
Cell Tissue Res. 1983;231(1):29-37. doi: 10.1007/BF00215771.
10
Transforming growth factor beta regulates the levels of different fibronectin isoforms in normal human cultured fibroblasts.
FEBS Lett. 1988 Feb 8;228(1):42-4. doi: 10.1016/0014-5793(88)80580-5.
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